The study focused on investigating the contribution of reclamation strategies of saline-sodic soils and their impacts on soil fertility characteristics. In this study, the soil treatments were denoted as: SG1 and SG2 (23.8 and 47.7 ton/ha of spent grain); TC1 and TC2 (23.8 and 47.6 ton/ha of compost); Azospirillium in inoculation with seed and soil (Az); Az + SG1 (Az+SG1); Az + TC1 (Az+TC1); mineral fertilizers (NPK); and control (CK). All treatments were mixed in pots with 30 kg soil. The results showed that reclamation with Az and SG2 treatments significantly affected soil pH, EC, and macronutrients. In contrast, no significant (P > 0.05) effects were found with the two compost levels and NPK treatments. The salt contents were maximal in the control treatment, while decreased with Az, SG2, and Az+SG treatments. However, SG2 application decreased the soluble Na+ concentrations in soil solution. The effect of organic and biological reclamations on chemical properties was in the following order: Az+SG > SG2 > Az > TC2 > Az+M > SG1 > TC1 > NPK > CK. Moreover, it positively impacted the salt contents, which improved soil chemical properties in the saline-sodic soil after three months of seed sowing in the greenhouse.