Research output: Contribution to journal › Article › peer-review
The mechanisms of epigenetic inheritance: How diverse are they? / Тиходеев, Олег Николаевич.
In: Biological Reviews, Vol. 93, No. 4, 11.2018, p. 1987-2005.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The mechanisms of epigenetic inheritance: How diverse are they?
AU - Тиходеев, Олег Николаевич
PY - 2018/11
Y1 - 2018/11
N2 - Although epigenetic inheritance (EI) is a rapidly growing field of modern biology, it still has no clear place in fundamental genetic concepts which are traditionally based on the hereditary role of DNA. Moreover, not all mechanisms of EI attract the same attention, with most studies focused on DNA methylation, histone modification, RNA interference and amyloid prionization, but relatively few considering other mechanisms such as stable inhibition of plastid translation. Herein, we discuss all known and some hypothetical mechanisms that can underlie the stable inheritance of phenotypically distinct hereditary factors that lack differences in DNA sequence. These mechanisms include (i) regulation of transcription by DNA methylation, histone modifications, and transcription factors, (ii) RNA splicing, (iii) RNA-mediated post-transcriptional silencing, (iv) organellar translation, (v) protein processing by truncation, (vi) post-translational chemical modifications, (vii) protein folding, and (viii) homologous and non-homologous protein interactions. The breadth of this list suggests that any or almost any regulatory mechanism that participates in gene expression or gene-product functioning, under certain circumstances, may produce EI. Although the modes of EI are highly variable, in many epigenetic systems, stable allelic variants can be distinguished. Irrespective of their nature, all such alleles have an underlying similarity: each is a bimodular hereditary unit, whose features depend on (i) a certain epigenetic mark (epigenetic determinant) in the DNA sequence or its product, and (ii) the DNA sequence itself (DNA determinant; if this is absent, the epigenetic allele fails to perpetuate). Thus, stable allelic epigenetic inheritance (SAEI) does not contradict the hereditary role of DNA, but involves additional molecular mechanisms with no or almost no limitations to their variety.
AB - Although epigenetic inheritance (EI) is a rapidly growing field of modern biology, it still has no clear place in fundamental genetic concepts which are traditionally based on the hereditary role of DNA. Moreover, not all mechanisms of EI attract the same attention, with most studies focused on DNA methylation, histone modification, RNA interference and amyloid prionization, but relatively few considering other mechanisms such as stable inhibition of plastid translation. Herein, we discuss all known and some hypothetical mechanisms that can underlie the stable inheritance of phenotypically distinct hereditary factors that lack differences in DNA sequence. These mechanisms include (i) regulation of transcription by DNA methylation, histone modifications, and transcription factors, (ii) RNA splicing, (iii) RNA-mediated post-transcriptional silencing, (iv) organellar translation, (v) protein processing by truncation, (vi) post-translational chemical modifications, (vii) protein folding, and (viii) homologous and non-homologous protein interactions. The breadth of this list suggests that any or almost any regulatory mechanism that participates in gene expression or gene-product functioning, under certain circumstances, may produce EI. Although the modes of EI are highly variable, in many epigenetic systems, stable allelic variants can be distinguished. Irrespective of their nature, all such alleles have an underlying similarity: each is a bimodular hereditary unit, whose features depend on (i) a certain epigenetic mark (epigenetic determinant) in the DNA sequence or its product, and (ii) the DNA sequence itself (DNA determinant; if this is absent, the epigenetic allele fails to perpetuate). Thus, stable allelic epigenetic inheritance (SAEI) does not contradict the hereditary role of DNA, but involves additional molecular mechanisms with no or almost no limitations to their variety.
KW - epigenetic inheritance
KW - DNA methylation
KW - histone modification
KW - chromatin remodelling
KW - bistable gene networks
KW - hereditary prions
KW - RNA interference
KW - self-splicing
KW - trans-generation memory
KW - body-to-body information transfer.
KW - epigenetic inheritance
KW - DNA methylation
KW - histone modification
KW - chromatin remodelling
KW - bistable gene networks
KW - hereditary prions
KW - RNA interference
KW - self-splicing
KW - trans-generation memory
KW - body-to-body information transfer.
KW - body-to-body information transfer
KW - DEOXYRIBONUCLEIC-ACID
KW - POLYPEPTIDE-CHAIN
KW - ARABIDOPSIS-THALIANA
KW - SMALL RNAS
KW - DNA METHYLATION
KW - PODOSPORA-ANSERINA
KW - GROUP-I INTRONS
KW - YEAST SACCHAROMYCES-CEREVISIAE
KW - GENE-EXPRESSION
KW - TRANSGENERATIONAL INHERITANCE
UR - http://www.scopus.com/inward/record.url?scp=85047498624&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/mechanisms-epigenetic-inheritance-diverse
U2 - doi: 10.1111/brv.12429
DO - doi: 10.1111/brv.12429
M3 - Article
VL - 93
SP - 1987
EP - 2005
JO - Biological Reviews
JF - Biological Reviews
SN - 1464-7931
IS - 4
ER -
ID: 35735217