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The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis. / Natochin, Yu V.; Shakhmatova, E. I.; Bogolepova, A. E.

In: Doklady Biochemistry and Biophysics, Vol. 497, No. 1, 01.03.2021, p. 95-98.

Research output: Contribution to journal › Article › peer-review

Harvard

Natochin, YV, Shakhmatova, EI & Bogolepova, AE 2021, 'The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis', Doklady Biochemistry and Biophysics, vol. 497, no. 1, pp. 95-98. https://doi.org/10.1134/S1607672921020113

APA

Natochin, Y. V., Shakhmatova, E. I., & Bogolepova, A. E. (2021). The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis. Doklady Biochemistry and Biophysics, 497(1), 95-98. https://doi.org/10.1134/S1607672921020113

Vancouver

Natochin YV, Shakhmatova EI, Bogolepova AE. The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis. Doklady Biochemistry and Biophysics. 2021 Mar 1;497(1):95-98. https://doi.org/10.1134/S1607672921020113

Author

Natochin, Yu V. ; Shakhmatova, E. I. ; Bogolepova, A. E. / The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis. In: Doklady Biochemistry and Biophysics. 2021 ; Vol. 497, No. 1. pp. 95-98.

BibTeX

@article{62df1b0f7ca84bf881ff0431460bb037,
title = "The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis",
abstract = "Abstract: We found an experimental solution to the paradox when the reabsorption of solute-free water increases with a simultaneous increase in diuresis and saluresis in the rat kidney under the oxytocin action. Injection of oxytocin to rats (0.25 nmol/100 g of body weight) increases diuresis from 0.16 ± 0.03 to 0.26 ± 0.02 mL/h, the excretion of solutes from 134 ± 13.7 to 300 ± 16.3 μOsm/h, and the reabsorption of solute-free water, which correlates with the renal excretion of oxytocin (p < 0.001). The mechanism of the effect is that oxytocin decreases the reabsorption of ultrafiltrate in the proximal tubule (the clearance of lithium increases) and increases the fluid flow through the distal segment of the nephron. In vivarium rats, urine osmolality (1010 ± 137 mOsm/kg H2O) and the concentration of vasopressin are high, this causes an increase in the reabsorption of solute-free water. Thus, oxytocin increases saluresis, which, against the background of a high level of endogenous vasopressin, increases the water reabsorption in the collecting ducts.",
keywords = "kidney, oxytocin, reabsorption of solute-free water, saluresis, vasopressin",
author = "Natochin, {Yu V.} and Shakhmatova, {E. I.} and Bogolepova, {A. E.}",
year = "2021",
month = mar,
day = "1",
doi = "10.1134/S1607672921020113",
language = "English",
volume = "497",
pages = "95--98",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "1",

}

RIS

TY - JOUR

T1 - The Mechanism of the Solute-Free Water Reabsorption Increase in the Rat Kidney by Oxytocin Saluresis

AU - Natochin, Yu V.

AU - Shakhmatova, E. I.

AU - Bogolepova, A. E.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Abstract: We found an experimental solution to the paradox when the reabsorption of solute-free water increases with a simultaneous increase in diuresis and saluresis in the rat kidney under the oxytocin action. Injection of oxytocin to rats (0.25 nmol/100 g of body weight) increases diuresis from 0.16 ± 0.03 to 0.26 ± 0.02 mL/h, the excretion of solutes from 134 ± 13.7 to 300 ± 16.3 μOsm/h, and the reabsorption of solute-free water, which correlates with the renal excretion of oxytocin (p < 0.001). The mechanism of the effect is that oxytocin decreases the reabsorption of ultrafiltrate in the proximal tubule (the clearance of lithium increases) and increases the fluid flow through the distal segment of the nephron. In vivarium rats, urine osmolality (1010 ± 137 mOsm/kg H2O) and the concentration of vasopressin are high, this causes an increase in the reabsorption of solute-free water. Thus, oxytocin increases saluresis, which, against the background of a high level of endogenous vasopressin, increases the water reabsorption in the collecting ducts.

AB - Abstract: We found an experimental solution to the paradox when the reabsorption of solute-free water increases with a simultaneous increase in diuresis and saluresis in the rat kidney under the oxytocin action. Injection of oxytocin to rats (0.25 nmol/100 g of body weight) increases diuresis from 0.16 ± 0.03 to 0.26 ± 0.02 mL/h, the excretion of solutes from 134 ± 13.7 to 300 ± 16.3 μOsm/h, and the reabsorption of solute-free water, which correlates with the renal excretion of oxytocin (p < 0.001). The mechanism of the effect is that oxytocin decreases the reabsorption of ultrafiltrate in the proximal tubule (the clearance of lithium increases) and increases the fluid flow through the distal segment of the nephron. In vivarium rats, urine osmolality (1010 ± 137 mOsm/kg H2O) and the concentration of vasopressin are high, this causes an increase in the reabsorption of solute-free water. Thus, oxytocin increases saluresis, which, against the background of a high level of endogenous vasopressin, increases the water reabsorption in the collecting ducts.

KW - kidney

KW - oxytocin

KW - reabsorption of solute-free water

KW - saluresis

KW - vasopressin

UR - http://www.scopus.com/inward/record.url?scp=85102207991&partnerID=8YFLogxK

U2 - 10.1134/S1607672921020113

DO - 10.1134/S1607672921020113

M3 - Article

C2 - 33666805

AN - SCOPUS:85102207991

VL - 497

SP - 95

EP - 98

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -

ID: 110897785