The application of the local polynomial splines to the solution of integro-differential equations was regarded in the author’s previous papers. In a recent paper, we introduced the application of the local nonpolynomial splines to the solution of integro-differential equations. These splines allow us to approximate
functions with a presribed order of approximation. In this paper, we apply the splines to the solution of the integro-differential equations with a smooth kernel. Applying the trigonometric or exponential spline approximations of the fifth order of approximation, we obtain an approximate solution of the integrodifferential equation at the set of nodes. The advantages of using such splines include the ability to determine not only the values of the desired function at the grid nodes, but also the first derivative at the grid nodes. The obtained values can be connected by lines using the splines. Thus, after interpolation, we can obtain the value of the solution at any point of the considered interval. Several numerical examples are given.