Abstract. Introduction. The patients’ behavior in the therapy process, especially their adherence to treatment, has a major impact on the treatment outcomes. The study of the factors that contribute to favorable ways of conduct will help improving the efficiency of patients’ rehabilitation. Aim. The aim of the research was to reveal some of the factors that may be related to patients’ with CHD behaviour in the therapy process, adherence to treatment in particular. Thereby two groups of patients after CABG were studied: adherent (n=53) and non-adherent to therapy (n=50). Methods: a detailed study of the patients’ medical records and the results of medical examinations, a detailed study of patients’ biography, their social status and so on, and several psychological questionnaires, the Lazarus and Folkman Ways of Coping Questionnaire, adapted and standardized by Vasserman et al. (2009) among them. Results. As a result of the study, a number of factors significantly associated with patients’ adherence to therapy were identified, including biological, psychosocial, and psychological factors. It was found that the duration of CHD by the time of surgery is a factor which significantly differs two groups of patients (χ2= 17,018; p<0,001), patients with a longer duration of CHD (more than 6 years) had a better adherence to treatment. Among the psychosocial factors that were studied, the patients’ motivation to continue working after the surgery due to the desire to self-actualization (χ2= 4,719; p<0,05) was found to be a factor preventing the patient from violating the therapeutic regimen. It was found that adherent to therapy patients show higher values on the scales related to the “self-controlling” (F=16,15; p<0,001) and “positive reappraisal” (F=27,82; p<0,001) ways of coping. Conclusion. According to the data obtained, it is essential to consider that a unique combination of various factors – medical, socioeconomic and psychological among them – determines the behaviour of patients after CABG in the therapy process, including their adherence to treatment.