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The interaction of DNA with piperazine derivatives of benzoimidazophthalazine. / Osinnikova, D.N.; Moroshkina, E.B.; Travkina, V.I.

In: Journal of Physics: Conference Series, Vol. 769, No. 1, 012021, 2016.

Research output: Contribution to journal › Article › peer-review

Harvard

Osinnikova, DN, Moroshkina, EB & Travkina, VI 2016, 'The interaction of DNA with piperazine derivatives of benzoimidazophthalazine', Journal of Physics: Conference Series, vol. 769, no. 1, 012021. https://doi.org/10.1088/1742-6596/769/1/012021

APA

Osinnikova, D. N., Moroshkina, E. B., & Travkina, V. I. (2016). The interaction of DNA with piperazine derivatives of benzoimidazophthalazine. Journal of Physics: Conference Series, 769(1), [012021]. https://doi.org/10.1088/1742-6596/769/1/012021

Vancouver

Osinnikova DN, Moroshkina EB, Travkina VI. The interaction of DNA with piperazine derivatives of benzoimidazophthalazine. Journal of Physics: Conference Series. 2016;769(1). 012021. https://doi.org/10.1088/1742-6596/769/1/012021

Author

Osinnikova, D.N. ; Moroshkina, E.B. ; Travkina, V.I. / The interaction of DNA with piperazine derivatives of benzoimidazophthalazine. In: Journal of Physics: Conference Series. 2016 ; Vol. 769, No. 1.

BibTeX

@article{c312ede159af497f89cb01aac60b53b2,
title = "The interaction of DNA with piperazine derivatives of benzoimidazophthalazine",
abstract = "Abstract. The interaction of DNA molecule with new synthetic compounds, piperazine derivatives of benzo[4,5]imidazo[1,2-a]phthalazine, was investigated by the spectral, hydrodynamic and optical methods. The thermodynamic parameters of the interaction and the stoichiometry of the complexes were determined by spectrophotometric titration. A mode of binding and structure of the complexes were determined by analyzing the changes in the intrinsic viscosity and the optical anisotropy of the macromolecule upon complexation. It is shown that an increase in the intrinsic viscosity and the optical anisotropy with a small content of the ligand in the complex is caused by the increase in the thermodynamic rigidity of macromolecules upon the formation of the complex. Increase of the contour length of the macromolecule in the complex does not occur, that indicates nonintercalative mode of binding the piperazine derivatives of benzoimidazophthalazine with DNA.",
author = "D.N. Osinnikova and E.B. Moroshkina and V.I. Travkina",
year = "2016",
doi = "10.1088/1742-6596/769/1/012021",
language = "English",
volume = "769",
journal = "Journal of Physics: Conference Series",
issn = "1742-6588",
publisher = "IOP Publishing Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - The interaction of DNA with piperazine derivatives of benzoimidazophthalazine

AU - Osinnikova, D.N.

AU - Moroshkina, E.B.

AU - Travkina, V.I.

PY - 2016

Y1 - 2016

N2 - Abstract. The interaction of DNA molecule with new synthetic compounds, piperazine derivatives of benzo[4,5]imidazo[1,2-a]phthalazine, was investigated by the spectral, hydrodynamic and optical methods. The thermodynamic parameters of the interaction and the stoichiometry of the complexes were determined by spectrophotometric titration. A mode of binding and structure of the complexes were determined by analyzing the changes in the intrinsic viscosity and the optical anisotropy of the macromolecule upon complexation. It is shown that an increase in the intrinsic viscosity and the optical anisotropy with a small content of the ligand in the complex is caused by the increase in the thermodynamic rigidity of macromolecules upon the formation of the complex. Increase of the contour length of the macromolecule in the complex does not occur, that indicates nonintercalative mode of binding the piperazine derivatives of benzoimidazophthalazine with DNA.

AB - Abstract. The interaction of DNA molecule with new synthetic compounds, piperazine derivatives of benzo[4,5]imidazo[1,2-a]phthalazine, was investigated by the spectral, hydrodynamic and optical methods. The thermodynamic parameters of the interaction and the stoichiometry of the complexes were determined by spectrophotometric titration. A mode of binding and structure of the complexes were determined by analyzing the changes in the intrinsic viscosity and the optical anisotropy of the macromolecule upon complexation. It is shown that an increase in the intrinsic viscosity and the optical anisotropy with a small content of the ligand in the complex is caused by the increase in the thermodynamic rigidity of macromolecules upon the formation of the complex. Increase of the contour length of the macromolecule in the complex does not occur, that indicates nonintercalative mode of binding the piperazine derivatives of benzoimidazophthalazine with DNA.

U2 - 10.1088/1742-6596/769/1/012021

DO - 10.1088/1742-6596/769/1/012021

M3 - Article

VL - 769

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

SN - 1742-6588

IS - 1

M1 - 012021

ER -

ID: 7653861