The glutathione system in the subcellular fractions of developing rat brain and liver

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The glutathione system in the subcellular fractions of developing rat brain and liver. / Galkina, O. V.; Bakhtyukov, A. A.; Akhmetshin, M. O.; Prokopenko, V. M.; Eshchenko, N. D.

In: Neurochemical Journal, Vol. 11, No. 4, 01.10.2017, p. 266-271.

Research output: Contribution to journal › Article › peer-review

Author

Galkina, O. V. ; Bakhtyukov, A. A. ; Akhmetshin, M. O. ; Prokopenko, V. M. ; Eshchenko, N. D. / The glutathione system in the subcellular fractions of developing rat brain and liver. In: Neurochemical Journal. 2017 ; Vol. 11, No. 4. pp. 266-271.

BibTeX

@article{88b1aca0c64c4e40bd47f3a1b36ebe99,

title = "The glutathione system in the subcellular fractions of developing rat brain and liver",

abstract = "In the present study, we estimated the levels of various forms of glutathione and the state of the glutathione antioxidant system in the subcellular fractions of the rat brain and in the liver during early postnatal ontogeny. Several groups of animals were studied, including 10-, 20-, and 30-day-old male Wistar rats, which allowed us to study different periods of brain maturation. It was shown that during the postnatal development of the rat brain from day 10 to day 30 the contents of both reduced and oxidized forms of glutathione decreased. In early ontogeny, when the activity of most of antioxidant enzymes is low, reduced glutathione may perform an antioxidant function. On the other hand, despite the decrease in the absolute value, the portion of GSH in the total glutathione pool increased and modified the redox state of the cells toward a more reduced condition. The decrease in the GSH level may be related to lower activity of glutathione reductase, which reduces oxidized glutathione, or to increased activity of the antioxidant enzymes, such as glutathione peroxidase and glutathione-S-transferase, which use GSH as a cofactor in their reactions.",

keywords = "developing brain, enzymatic antioxidants, glutathione reductase, glutathione-S-transferase, reduced and oxidized glutathione, subcellular fractions",

author = "Galkina, {O. V.} and Bakhtyukov, {A. A.} and Akhmetshin, {M. O.} and Prokopenko, {V. M.} and Eshchenko, {N. D.}",

note = "Publisher Copyright: {\textcopyright} 2017, Pleiades Publishing, Ltd.",

year = "2017",

month = oct,

day = "1",

doi = "10.1134/S1819712417030047",

language = "English",

volume = "11",

pages = "266--271",

journal = "Neurochemical Journal",

issn = "1819-7124",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "4",

}

RIS

TY - JOUR

T1 - The glutathione system in the subcellular fractions of developing rat brain and liver

AU - Galkina, O. V.

AU - Bakhtyukov, A. A.

AU - Akhmetshin, M. O.

AU - Prokopenko, V. M.

AU - Eshchenko, N. D.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - In the present study, we estimated the levels of various forms of glutathione and the state of the glutathione antioxidant system in the subcellular fractions of the rat brain and in the liver during early postnatal ontogeny. Several groups of animals were studied, including 10-, 20-, and 30-day-old male Wistar rats, which allowed us to study different periods of brain maturation. It was shown that during the postnatal development of the rat brain from day 10 to day 30 the contents of both reduced and oxidized forms of glutathione decreased. In early ontogeny, when the activity of most of antioxidant enzymes is low, reduced glutathione may perform an antioxidant function. On the other hand, despite the decrease in the absolute value, the portion of GSH in the total glutathione pool increased and modified the redox state of the cells toward a more reduced condition. The decrease in the GSH level may be related to lower activity of glutathione reductase, which reduces oxidized glutathione, or to increased activity of the antioxidant enzymes, such as glutathione peroxidase and glutathione-S-transferase, which use GSH as a cofactor in their reactions.

AB - In the present study, we estimated the levels of various forms of glutathione and the state of the glutathione antioxidant system in the subcellular fractions of the rat brain and in the liver during early postnatal ontogeny. Several groups of animals were studied, including 10-, 20-, and 30-day-old male Wistar rats, which allowed us to study different periods of brain maturation. It was shown that during the postnatal development of the rat brain from day 10 to day 30 the contents of both reduced and oxidized forms of glutathione decreased. In early ontogeny, when the activity of most of antioxidant enzymes is low, reduced glutathione may perform an antioxidant function. On the other hand, despite the decrease in the absolute value, the portion of GSH in the total glutathione pool increased and modified the redox state of the cells toward a more reduced condition. The decrease in the GSH level may be related to lower activity of glutathione reductase, which reduces oxidized glutathione, or to increased activity of the antioxidant enzymes, such as glutathione peroxidase and glutathione-S-transferase, which use GSH as a cofactor in their reactions.

KW - developing brain

KW - enzymatic antioxidants

KW - glutathione reductase

KW - glutathione-S-transferase

KW - reduced and oxidized glutathione

KW - subcellular fractions

UR - http://www.scopus.com/inward/record.url?scp=85037349076&partnerID=8YFLogxK

U2 - 10.1134/S1819712417030047

DO - 10.1134/S1819712417030047

M3 - Article

AN - SCOPUS:85037349076

VL - 11

SP - 266

EP - 271

JO - Neurochemical Journal

JF - Neurochemical Journal

SN - 1819-7124

IS - 4

ER -

ID: 86142947