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The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing. / Bajenova, Olga; Gorbunova, Anna; Evsyukov, Igor; Rayko, Michael; Gapon, Svetlana; Bozhokina, Ekaterina; Shishkin, Alexander; O'Brien, Stephen J.

In: PLoS ONE, Vol. 11, No. 9, 2016.

Research output: Contribution to journal › Article › peer-review

Harvard

Bajenova, O, Gorbunova, A, Evsyukov, I, Rayko, M, Gapon, S, Bozhokina, E, Shishkin, A & O'Brien, SJ 2016, 'The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing', PLoS ONE, vol. 11, no. 9. https://doi.org/10.1371/journal.pone.0161256, https://doi.org/10.1371/journal.pone.0161256

APA

Bajenova, O., Gorbunova, A., Evsyukov, I., Rayko, M., Gapon, S., Bozhokina, E., Shishkin, A., & O'Brien, S. J. (2016). The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing. PLoS ONE, 11(9). https://doi.org/10.1371/journal.pone.0161256, https://doi.org/10.1371/journal.pone.0161256

Vancouver

Bajenova O, Gorbunova A, Evsyukov I, Rayko M, Gapon S, Bozhokina E et al. The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing. PLoS ONE. 2016;11(9). https://doi.org/10.1371/journal.pone.0161256, https://doi.org/10.1371/journal.pone.0161256

Author

Bajenova, Olga ; Gorbunova, Anna ; Evsyukov, Igor ; Rayko, Michael ; Gapon, Svetlana ; Bozhokina, Ekaterina ; Shishkin, Alexander ; O'Brien, Stephen J. / The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing. In: PLoS ONE. 2016 ; Vol. 11, No. 9.

BibTeX

@article{2dca7da61fdd42d9af198d7749011fb1,
title = "The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing",
abstract = "Carcinoembryonic antigen (CEA, CEACAM5, CD66) is a promoter of metastasis in epithelial cancers that is widely used as a prognostic clinical marker of metastasis. The aim of this study is to identify the network of genes that are associated with CEA-induced colorectal cancer liver metastasis. We compared the genome-wide transcriptomic profiles of CEA positive (MIP101 clone 8) and CEA negative (MIP 101) colorectal cancer cell lines with different metastatic potential in vivo. The CEA-producing cells displayed quantitative changes in the level of expression for 100 genes (over-expressed or down-regulated). They were confirmed by quantitative RT-PCR. The KEGG pathway analysis identified 4 significantly enriched pathways: cytokine-cytokine receptor interaction, MAPK signaling pathway, TGFbeta signaling pathway and pyrimidine metabolism. Our results suggest that CEA production by colorectal cancer cells triggers colorectal cancer progression by inducing the epithelial-mesenchymal transition, increasing tumor cell",
author = "Olga Bajenova and Anna Gorbunova and Igor Evsyukov and Michael Rayko and Svetlana Gapon and Ekaterina Bozhokina and Alexander Shishkin and O'Brien, {Stephen J.}",
year = "2016",
doi = "10.1371/journal.pone.0161256",
language = "English",
volume = "11",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing

AU - Bajenova, Olga

AU - Gorbunova, Anna

AU - Evsyukov, Igor

AU - Rayko, Michael

AU - Gapon, Svetlana

AU - Bozhokina, Ekaterina

AU - Shishkin, Alexander

AU - O'Brien, Stephen J.

PY - 2016

Y1 - 2016

N2 - Carcinoembryonic antigen (CEA, CEACAM5, CD66) is a promoter of metastasis in epithelial cancers that is widely used as a prognostic clinical marker of metastasis. The aim of this study is to identify the network of genes that are associated with CEA-induced colorectal cancer liver metastasis. We compared the genome-wide transcriptomic profiles of CEA positive (MIP101 clone 8) and CEA negative (MIP 101) colorectal cancer cell lines with different metastatic potential in vivo. The CEA-producing cells displayed quantitative changes in the level of expression for 100 genes (over-expressed or down-regulated). They were confirmed by quantitative RT-PCR. The KEGG pathway analysis identified 4 significantly enriched pathways: cytokine-cytokine receptor interaction, MAPK signaling pathway, TGFbeta signaling pathway and pyrimidine metabolism. Our results suggest that CEA production by colorectal cancer cells triggers colorectal cancer progression by inducing the epithelial-mesenchymal transition, increasing tumor cell

AB - Carcinoembryonic antigen (CEA, CEACAM5, CD66) is a promoter of metastasis in epithelial cancers that is widely used as a prognostic clinical marker of metastasis. The aim of this study is to identify the network of genes that are associated with CEA-induced colorectal cancer liver metastasis. We compared the genome-wide transcriptomic profiles of CEA positive (MIP101 clone 8) and CEA negative (MIP 101) colorectal cancer cell lines with different metastatic potential in vivo. The CEA-producing cells displayed quantitative changes in the level of expression for 100 genes (over-expressed or down-regulated). They were confirmed by quantitative RT-PCR. The KEGG pathway analysis identified 4 significantly enriched pathways: cytokine-cytokine receptor interaction, MAPK signaling pathway, TGFbeta signaling pathway and pyrimidine metabolism. Our results suggest that CEA production by colorectal cancer cells triggers colorectal cancer progression by inducing the epithelial-mesenchymal transition, increasing tumor cell

U2 - 10.1371/journal.pone.0161256

DO - 10.1371/journal.pone.0161256

M3 - Article

VL - 11

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

ER -

ID: 7951511