Research output: Contribution to journal › Article › peer-review
The first selenium containing chitin and chitosan derivatives: Combined synthetic, catalytic and biological studies. / Егоров, Антон; Омар, Хубиев; Рубаник, Василий; Рубаник (мл.), Василий; Лобанов, Николай; Критченков, Илья Сергеевич; Савилов, Сергей; Киричук, Анатолий; Цховребов, Александр Георгиевич; Критченков, Андрей.
In: International Journal of Biological Macromolecules, Vol. 209, No. Part B, 01.06.2022, p. 2175-2187.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The first selenium containing chitin and chitosan derivatives: Combined synthetic, catalytic and biological studies
AU - Егоров, Антон
AU - Омар, Хубиев
AU - Рубаник, Василий
AU - Рубаник (мл.), Василий
AU - Лобанов, Николай
AU - Критченков, Илья Сергеевич
AU - Савилов, Сергей
AU - Киричук, Анатолий
AU - Цховребов, Александр Георгиевич
AU - Критченков, Андрей
N1 - Publisher Copyright: © 2022 Elsevier B.V.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Ultrasonic approach to the synthesis of the first selenium-containing derivatives of chitin and chitosan has been developed. The synthetic procedure is simple, provides high yields, does not require harsh conditions, and uses water as the reaction medium. The elaborated chitin and chitosan derivatives and their based nanoparticles are non-toxic and possess high antibacterial and antifungal activity. Their antimicrobial activity exceeds the effect of the classic antibiotics (Ampicillin and Gentamicin) and the antifungal drug Amphotericin B. The obtained selenium-containing cationic chitin and chitosan derivatives exhibit a high transfection activity and are promising gene delivery vectors. Nanoparticles of the synthesized polymers are highly efficient catalysts for the oxidation of 1-phenylethyl alcohol to acetophenone by bromine at room temperature.
AB - Ultrasonic approach to the synthesis of the first selenium-containing derivatives of chitin and chitosan has been developed. The synthetic procedure is simple, provides high yields, does not require harsh conditions, and uses water as the reaction medium. The elaborated chitin and chitosan derivatives and their based nanoparticles are non-toxic and possess high antibacterial and antifungal activity. Their antimicrobial activity exceeds the effect of the classic antibiotics (Ampicillin and Gentamicin) and the antifungal drug Amphotericin B. The obtained selenium-containing cationic chitin and chitosan derivatives exhibit a high transfection activity and are promising gene delivery vectors. Nanoparticles of the synthesized polymers are highly efficient catalysts for the oxidation of 1-phenylethyl alcohol to acetophenone by bromine at room temperature.
KW - Antimicrobial activity
KW - Chitin
KW - Chitosan
KW - Selenium
KW - Transfection activity
UR - http://www.scopus.com/inward/record.url?scp=85129760386&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/c186db73-0563-3514-881a-1ef444ffb007/
U2 - 10.1016/j.ijbiomac.2022.04.199
DO - 10.1016/j.ijbiomac.2022.04.199
M3 - Article
VL - 209
SP - 2175
EP - 2187
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
IS - Part B
ER -
ID: 96210689