Links

Pharmacokinetic studies were performed at 120 white mice after intravenous injection of 5.3 MBq/kg 99m Tc-ciprofloxacin into the femoral venue. Blood and organs radiometry was made using gamma spectrometer 'Tracor Analytic'. Suitability of bacterial infection imaging using this radiopharmaceutical studied with two groups of laboratory animals. The first group includes 5 rabbits with abscess and the second - 5 with aseptic inflammation. Scintigrafic imaging of experimental bacterial infection in rabbits is most successful at 1.5-2 hours after intravenous injection of 99m Tc-ciprofloxacin. Pharmacokinetic studies showed the urinogenous system as main in radiopharmaceutical elimination. The biological half-elimination period of radiopharmaceutical's is 135 minutes. Summary accumulation of 99m Tc-ciprofloxacin in organs is not more than 10% of injected dose. The study shows that 99m Tc-ciprofloxacin is harmless and suitable for diagnoses of bacterial infection.

Translated title of the contributionЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ 99MTC-ЦИПРОФЛОКСАСИНА ДЛЯ ДИАГНОСТИКИ БАКТЕРИАЛЬНОЙ ИНФЕКЦИИ
Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalMeditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
Volume47
Issue number4
StatePublished - 2002
Externally publishedYes

    Research areas

  • Bacterial infection, Diagnosis, Pharmacokinetic, The Tc-ciprofloxacin

    Scopus subject areas

  • Health Professions(all)

ID: 45772808