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The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation : Translational lessons from zebrafish. / Genario, Rafael; Giacomini, Ana C.V.V.; Demin, Konstantin A.; dos Santos, Bruna E.; Marchiori, Natalia I.; Volgin, Angrey D.; Bashirzade, Alim; Amstislavskaya, Tamara G.; de Abreu, Murilo S.; Kalueff, Allan V.

In: Neuroscience and Biobehavioral Reviews, Vol. 99, 01.04.2019, p. 117-127.

Research output: Contribution to journal › Review article › peer-review

Harvard

Genario, R, Giacomini, ACVV, Demin, KA, dos Santos, BE, Marchiori, NI, Volgin, AD, Bashirzade, A, Amstislavskaya, TG, de Abreu, MS & Kalueff, AV 2019, 'The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish', Neuroscience and Biobehavioral Reviews, vol. 99, pp. 117-127. https://doi.org/10.1016/j.neubiorev.2018.12.025

APA

Genario, R., Giacomini, A. C. V. V., Demin, K. A., dos Santos, B. E., Marchiori, N. I., Volgin, A. D., Bashirzade, A., Amstislavskaya, T. G., de Abreu, M. S., & Kalueff, A. V. (2019). The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish. Neuroscience and Biobehavioral Reviews, 99, 117-127. https://doi.org/10.1016/j.neubiorev.2018.12.025

Vancouver

Genario R, Giacomini ACVV, Demin KA, dos Santos BE, Marchiori NI, Volgin AD et al. The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish. Neuroscience and Biobehavioral Reviews. 2019 Apr 1;99:117-127. https://doi.org/10.1016/j.neubiorev.2018.12.025

Author

Genario, Rafael ; Giacomini, Ana C.V.V. ; Demin, Konstantin A. ; dos Santos, Bruna E. ; Marchiori, Natalia I. ; Volgin, Angrey D. ; Bashirzade, Alim ; Amstislavskaya, Tamara G. ; de Abreu, Murilo S. ; Kalueff, Allan V. / The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation : Translational lessons from zebrafish. In: Neuroscience and Biobehavioral Reviews. 2019 ; Vol. 99. pp. 117-127.

BibTeX

@article{3bfa72bed123487a9852d2d41e21bbd4,
title = "The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish",
abstract = "Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.",
keywords = "Animal model, Behavioral regulation, CNS, Genetic model, Melatonin, Humans, Brain/drug effects, Animals, Zebrafish/physiology, Behavior, Animal/drug effects, Melatonin/pharmacology, Central Nervous System Diseases/drug therapy, Disease Models, Animal",
author = "Rafael Genario and Giacomini, {Ana C.V.V.} and Demin, {Konstantin A.} and {dos Santos}, {Bruna E.} and Marchiori, {Natalia I.} and Volgin, {Angrey D.} and Alim Bashirzade and Amstislavskaya, {Tamara G.} and {de Abreu}, {Murilo S.} and Kalueff, {Allan V.}",
year = "2019",
month = apr,
day = "1",
doi = "10.1016/j.neubiorev.2018.12.025",
language = "English",
volume = "99",
pages = "117--127",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation

T2 - Translational lessons from zebrafish

AU - Genario, Rafael

AU - Giacomini, Ana C.V.V.

AU - Demin, Konstantin A.

AU - dos Santos, Bruna E.

AU - Marchiori, Natalia I.

AU - Volgin, Angrey D.

AU - Bashirzade, Alim

AU - Amstislavskaya, Tamara G.

AU - de Abreu, Murilo S.

AU - Kalueff, Allan V.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.

AB - Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.

KW - Animal model

KW - Behavioral regulation

KW - CNS

KW - Genetic model

KW - Melatonin

KW - Humans

KW - Brain/drug effects

KW - Animals

KW - Zebrafish/physiology

KW - Behavior, Animal/drug effects

KW - Melatonin/pharmacology

KW - Central Nervous System Diseases/drug therapy

KW - Disease Models, Animal

UR - http://www.scopus.com/inward/record.url?scp=85061750125&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/evolutionarily-conserved-role-melatonin-cns-disorders-behavioral-regulation-translational-lessons-ze

U2 - 10.1016/j.neubiorev.2018.12.025

DO - 10.1016/j.neubiorev.2018.12.025

M3 - Review article

C2 - 30611799

AN - SCOPUS:85061750125

VL - 99

SP - 117

EP - 127

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -

ID: 47609794