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The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital. / Lazareva, Irina; Ageevets, Vladimir; Sopova, Julia; Lebedeva, Marina; Starkova, Polina; Likholetova, Daria; Lebedeva, Maria; Gostev, Vladimir; Moiseenko, Vladimir; Egorenkov, Vitaliy; Navatskaya, Arina; Mitroshina, Galina; Myasnikova, Elena; Tsvetkova, Irina; Lobzin, Yuri; Sidorenko, Sergey.

In: Infection, Genetics and Evolution, Vol. 85, 104527, 11.2020.

Research output: Contribution to journal › Article › peer-review

Harvard

Lazareva, I, Ageevets, V, Sopova, J, Lebedeva, M, Starkova, P, Likholetova, D, Lebedeva, M, Gostev, V, Moiseenko, V, Egorenkov, V, Navatskaya, A, Mitroshina, G, Myasnikova, E, Tsvetkova, I, Lobzin, Y & Sidorenko, S 2020, 'The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital', Infection, Genetics and Evolution, vol. 85, 104527. https://doi.org/10.1016/j.meegid.2020.104527

APA

Lazareva, I., Ageevets, V., Sopova, J., Lebedeva, M., Starkova, P., Likholetova, D., Lebedeva, M., Gostev, V., Moiseenko, V., Egorenkov, V., Navatskaya, A., Mitroshina, G., Myasnikova, E., Tsvetkova, I., Lobzin, Y., & Sidorenko, S. (2020). The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital. Infection, Genetics and Evolution, 85, [104527]. https://doi.org/10.1016/j.meegid.2020.104527

Vancouver

Lazareva I, Ageevets V, Sopova J, Lebedeva M, Starkova P, Likholetova D et al. The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital. Infection, Genetics and Evolution. 2020 Nov;85. 104527. https://doi.org/10.1016/j.meegid.2020.104527

Author

Lazareva, Irina ; Ageevets, Vladimir ; Sopova, Julia ; Lebedeva, Marina ; Starkova, Polina ; Likholetova, Daria ; Lebedeva, Maria ; Gostev, Vladimir ; Moiseenko, Vladimir ; Egorenkov, Vitaliy ; Navatskaya, Arina ; Mitroshina, Galina ; Myasnikova, Elena ; Tsvetkova, Irina ; Lobzin, Yuri ; Sidorenko, Sergey. / The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital. In: Infection, Genetics and Evolution. 2020 ; Vol. 85.

BibTeX

@article{d9ae1b6bb40b489faa4425a076e1f8ff,
title = "The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital",
abstract = "Fifteen hypermucoviscous isolates (13 blaNDM-1-positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD50 = 102 CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD50 = 104 CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD50 = 105 CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.",
keywords = "Antimicrobial resistance, Hypermucoviscous Klebsiella pneumoniae, New Delhi metallo-beta-lactamase 1, Virulence",
author = "Irina Lazareva and Vladimir Ageevets and Julia Sopova and Marina Lebedeva and Polina Starkova and Daria Likholetova and Maria Lebedeva and Vladimir Gostev and Vladimir Moiseenko and Vitaliy Egorenkov and Arina Navatskaya and Galina Mitroshina and Elena Myasnikova and Irina Tsvetkova and Yuri Lobzin and Sergey Sidorenko",
note = "Funding Information: The Russian Science Foundation (grant number 18-75-10117 ) supported this work. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = nov,
doi = "10.1016/j.meegid.2020.104527",
language = "English",
volume = "85",
journal = "Infection, Genetics and Evolution",
issn = "1567-1348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital

AU - Lazareva, Irina

AU - Ageevets, Vladimir

AU - Sopova, Julia

AU - Lebedeva, Marina

AU - Starkova, Polina

AU - Likholetova, Daria

AU - Lebedeva, Maria

AU - Gostev, Vladimir

AU - Moiseenko, Vladimir

AU - Egorenkov, Vitaliy

AU - Navatskaya, Arina

AU - Mitroshina, Galina

AU - Myasnikova, Elena

AU - Tsvetkova, Irina

AU - Lobzin, Yuri

AU - Sidorenko, Sergey

N1 - Funding Information: The Russian Science Foundation (grant number 18-75-10117 ) supported this work. Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/11

Y1 - 2020/11

N2 - Fifteen hypermucoviscous isolates (13 blaNDM-1-positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD50 = 102 CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD50 = 104 CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD50 = 105 CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.

AB - Fifteen hypermucoviscous isolates (13 blaNDM-1-positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD50 = 102 CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD50 = 104 CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD50 = 105 CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.

KW - Antimicrobial resistance

KW - Hypermucoviscous Klebsiella pneumoniae

KW - New Delhi metallo-beta-lactamase 1

KW - Virulence

UR - http://www.scopus.com/inward/record.url?scp=85090424589&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/ed7373f2-b946-3545-8c52-61c178023c9b/

U2 - 10.1016/j.meegid.2020.104527

DO - 10.1016/j.meegid.2020.104527

M3 - Article

C2 - 32898687

AN - SCOPUS:85090424589

VL - 85

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

SN - 1567-1348

M1 - 104527

ER -

ID: 71817195