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The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders. / Lavoie, Joëlle; Illiano, Placido; Sotnikova, Tatyana D.; Gainetdinov, Raul R.; Beaulieu, Jean-Martin; Hébert, Marc.

In: Biological Psychiatry, Vol. 75, No. 6, 2014, p. 479-486.

Research output: Contribution to journal › Article

Harvard

Lavoie, J, Illiano, P, Sotnikova, TD, Gainetdinov, RR, Beaulieu, J-M & Hébert, M 2014, 'The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders', Biological Psychiatry, vol. 75, no. 6, pp. 479-486. https://doi.org/10.1016/j.biopsych.2012.11.024

APA

Lavoie, J., Illiano, P., Sotnikova, T. D., Gainetdinov, R. R., Beaulieu, J-M., & Hébert, M. (2014). The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders. Biological Psychiatry, 75(6), 479-486. https://doi.org/10.1016/j.biopsych.2012.11.024

Vancouver

Lavoie J, Illiano P, Sotnikova TD, Gainetdinov RR, Beaulieu J-M, Hébert M. The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders. Biological Psychiatry. 2014;75(6):479-486. https://doi.org/10.1016/j.biopsych.2012.11.024

Author

Lavoie, Joëlle ; Illiano, Placido ; Sotnikova, Tatyana D. ; Gainetdinov, Raul R. ; Beaulieu, Jean-Martin ; Hébert, Marc. / The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders. In: Biological Psychiatry. 2014 ; Vol. 75, No. 6. pp. 479-486.

BibTeX

@article{5200992dac514011bd4a406596262f67,
title = "The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders",
abstract = "BACKGROUND: Dysfunctions in brain dopamine and serotonin neurotransmission are believed to be involved in the etiology of psychiatric disorders, and electroretinogram (ERG) anomalies have been reported in psychiatric patients. The goal of this study was to evaluate whether ERG anomalies could result from central dopamine or serotonin dysfunctions or from changes in the retinal bioavailability of these neurotransmitters. METHOD: Photopic and scotopic ERGs were recorded in R439H tryptophan hydroxylase 2 knockin (Tph2-KI) mice that have an approximately 80% decrease in brain serotonin and dopamine transporter knockout (DAT-KO) mice showing a fivefold increase in brain extracellular dopamine. Dopamine and serotonin retinal and striatal tissue content were also measured. The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG responses was evaluated in D1R-KO and D2R-KO mice. RESULTS: An increase in photopic b-wave implicit time was observed in Tph2-KI mice (wildtype = 24.25 msec, KI = 25.22 msec",
keywords = "Biomarker, dopamine, dopamine transporter, electroretinogram, psychiatric disorders, serotonin",
author = "Jo{\"e}lle Lavoie and Placido Illiano and Sotnikova, {Tatyana D.} and Gainetdinov, {Raul R.} and Jean-Martin Beaulieu and Marc H{\'e}bert",
year = "2014",
doi = "10.1016/j.biopsych.2012.11.024",
language = "English",
volume = "75",
pages = "479--486",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders

AU - Lavoie, Joëlle

AU - Illiano, Placido

AU - Sotnikova, Tatyana D.

AU - Gainetdinov, Raul R.

AU - Beaulieu, Jean-Martin

AU - Hébert, Marc

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Dysfunctions in brain dopamine and serotonin neurotransmission are believed to be involved in the etiology of psychiatric disorders, and electroretinogram (ERG) anomalies have been reported in psychiatric patients. The goal of this study was to evaluate whether ERG anomalies could result from central dopamine or serotonin dysfunctions or from changes in the retinal bioavailability of these neurotransmitters. METHOD: Photopic and scotopic ERGs were recorded in R439H tryptophan hydroxylase 2 knockin (Tph2-KI) mice that have an approximately 80% decrease in brain serotonin and dopamine transporter knockout (DAT-KO) mice showing a fivefold increase in brain extracellular dopamine. Dopamine and serotonin retinal and striatal tissue content were also measured. The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG responses was evaluated in D1R-KO and D2R-KO mice. RESULTS: An increase in photopic b-wave implicit time was observed in Tph2-KI mice (wildtype = 24.25 msec, KI = 25.22 msec

AB - BACKGROUND: Dysfunctions in brain dopamine and serotonin neurotransmission are believed to be involved in the etiology of psychiatric disorders, and electroretinogram (ERG) anomalies have been reported in psychiatric patients. The goal of this study was to evaluate whether ERG anomalies could result from central dopamine or serotonin dysfunctions or from changes in the retinal bioavailability of these neurotransmitters. METHOD: Photopic and scotopic ERGs were recorded in R439H tryptophan hydroxylase 2 knockin (Tph2-KI) mice that have an approximately 80% decrease in brain serotonin and dopamine transporter knockout (DAT-KO) mice showing a fivefold increase in brain extracellular dopamine. Dopamine and serotonin retinal and striatal tissue content were also measured. The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG responses was evaluated in D1R-KO and D2R-KO mice. RESULTS: An increase in photopic b-wave implicit time was observed in Tph2-KI mice (wildtype = 24.25 msec, KI = 25.22 msec

KW - Biomarker

KW - dopamine

KW - dopamine transporter

KW - electroretinogram

KW - psychiatric disorders

KW - serotonin

U2 - 10.1016/j.biopsych.2012.11.024

DO - 10.1016/j.biopsych.2012.11.024

M3 - Article

VL - 75

SP - 479

EP - 486

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 6

ER -

ID: 5714615