The effect of single nucleotide genetic polymorphisms of folic acid cycle on the female reproductive system disorders

Standard

The effect of single nucleotide genetic polymorphisms of folic acid cycle on the female reproductive system disorders. / Uvarova, M. A.; Ivanov, A.V.; Dedul, A. G.; Sheveleva, T. S.; Komlichenko, E. V.

In: Gynecological Endocrinology, Vol. 31, 05.10.2015, p. 34-38.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{25950314f8eb4ce492f886eb07dd6198,

title = "The effect of single nucleotide genetic polymorphisms of folic acid cycle on the female reproductive system disorders",

abstract = "Currently the significant part of reproductive disorders such as refractory pregnancy loss (RPL), infertility, unsuccessful in vitro fertilization (IVF) are thought to be connected with different genetic factors. One of the main hereditary risk factors for obstetrical pathology development is the presence of polymorph alleles in several genes of folic acid cycle. The present study is dedicated to investigation of the effect of folic acid cycle polymorph variants MTHFR C677 T, MTR A2756G and MTRR A66G on the RPL development and unsuccessful IVF. The samples of peripheral blood of 138 women were tested and showed a statistically significant increase of pathologic genetic alleles of MTRR A66G and MTHFR C677T frequency in two groups of patients with reproductive disorders, i.e. RPL and IVF, versus the control group. Also the advantage of simultaneous analysis of three folic cycle genetic polymorphisms at once in women with reproductive function disorder was demonstrated in comparison with the analysis of isolated polymorphism MTHFR C677T. The combination of polymorph alleles has a significant influence on the pathology development and by many times increases the risk of RPL development and unsuccessful IVF.",

keywords = "Folic acid cycle, IVF failure, miscarriage, SNP",

author = "Uvarova, {M. A.} and A.V. Ivanov and Dedul, {A. G.} and Sheveleva, {T. S.} and Komlichenko, {E. V.}",

note = "Publisher Copyright: {\textcopyright} 2015 {\textcopyright} 2015 Taylor & Francis.",

year = "2015",

month = oct,

day = "5",

doi = "10.3109/09513590.2015.1086504",

language = "English",

volume = "31",

pages = "34--38",

journal = "Gynecological Endocrinology",

issn = "0951-3590",

publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - The effect of single nucleotide genetic polymorphisms of folic acid cycle on the female reproductive system disorders

AU - Uvarova, M. A.

AU - Ivanov, A.V.

AU - Dedul, A. G.

AU - Sheveleva, T. S.

AU - Komlichenko, E. V.

PY - 2015/10/5

Y1 - 2015/10/5

N2 - Currently the significant part of reproductive disorders such as refractory pregnancy loss (RPL), infertility, unsuccessful in vitro fertilization (IVF) are thought to be connected with different genetic factors. One of the main hereditary risk factors for obstetrical pathology development is the presence of polymorph alleles in several genes of folic acid cycle. The present study is dedicated to investigation of the effect of folic acid cycle polymorph variants MTHFR C677 T, MTR A2756G and MTRR A66G on the RPL development and unsuccessful IVF. The samples of peripheral blood of 138 women were tested and showed a statistically significant increase of pathologic genetic alleles of MTRR A66G and MTHFR C677T frequency in two groups of patients with reproductive disorders, i.e. RPL and IVF, versus the control group. Also the advantage of simultaneous analysis of three folic cycle genetic polymorphisms at once in women with reproductive function disorder was demonstrated in comparison with the analysis of isolated polymorphism MTHFR C677T. The combination of polymorph alleles has a significant influence on the pathology development and by many times increases the risk of RPL development and unsuccessful IVF.

AB - Currently the significant part of reproductive disorders such as refractory pregnancy loss (RPL), infertility, unsuccessful in vitro fertilization (IVF) are thought to be connected with different genetic factors. One of the main hereditary risk factors for obstetrical pathology development is the presence of polymorph alleles in several genes of folic acid cycle. The present study is dedicated to investigation of the effect of folic acid cycle polymorph variants MTHFR C677 T, MTR A2756G and MTRR A66G on the RPL development and unsuccessful IVF. The samples of peripheral blood of 138 women were tested and showed a statistically significant increase of pathologic genetic alleles of MTRR A66G and MTHFR C677T frequency in two groups of patients with reproductive disorders, i.e. RPL and IVF, versus the control group. Also the advantage of simultaneous analysis of three folic cycle genetic polymorphisms at once in women with reproductive function disorder was demonstrated in comparison with the analysis of isolated polymorphism MTHFR C677T. The combination of polymorph alleles has a significant influence on the pathology development and by many times increases the risk of RPL development and unsuccessful IVF.

KW - Folic acid cycle

KW - IVF failure

KW - miscarriage

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=84943516780&partnerID=8YFLogxK

U2 - 10.3109/09513590.2015.1086504

DO - 10.3109/09513590.2015.1086504

M3 - Article

VL - 31

SP - 34

EP - 38

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

SN - 0951-3590

ER -

ID: 4004362