The effect of remantadine on the development of toxicosis caused by different influenza virus strains

Standard

The effect of remantadine on the development of toxicosis caused by different influenza virus strains. / Kiseleva, I. V.

In: Voprosy Virusologii, Vol. 26, No. 5, 1981, p. 541-543.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4b28b30e0c354d39ac2bc4e2f29e1781,

title = "The effect of remantadine on the development of toxicosis caused by different influenza virus strains",

abstract = "The effect of remantadine on the development of viral toxicosis caused in mice by original and remantadine-resistant strains of influenza virus was studied. A definite reduction of the antitoxic effectiveness of remantadine was demonstrated in passages of toxigenic influenza A virus strain in its presence. Prophylactic administration of remantadine protected mice from the development of toxic pulmonary edema and death caused by inoculation of a massive dose of influenza B virus. Passages of influenza B virus in the presence of remantadine produced a strain causing toxicosis in mice the course of which was not affected by remantadine any longer.",

author = "Kiseleva, {I. V.}",

year = "1981",

language = "English",

volume = "26",

pages = "541--543",

journal = "Вопросы вирусологии",

issn = "0507-4088",

publisher = "Медицина",

number = "5",

}

RIS

TY - JOUR

T1 - The effect of remantadine on the development of toxicosis caused by different influenza virus strains

AU - Kiseleva, I. V.

PY - 1981

Y1 - 1981

N2 - The effect of remantadine on the development of viral toxicosis caused in mice by original and remantadine-resistant strains of influenza virus was studied. A definite reduction of the antitoxic effectiveness of remantadine was demonstrated in passages of toxigenic influenza A virus strain in its presence. Prophylactic administration of remantadine protected mice from the development of toxic pulmonary edema and death caused by inoculation of a massive dose of influenza B virus. Passages of influenza B virus in the presence of remantadine produced a strain causing toxicosis in mice the course of which was not affected by remantadine any longer.

AB - The effect of remantadine on the development of viral toxicosis caused in mice by original and remantadine-resistant strains of influenza virus was studied. A definite reduction of the antitoxic effectiveness of remantadine was demonstrated in passages of toxigenic influenza A virus strain in its presence. Prophylactic administration of remantadine protected mice from the development of toxic pulmonary edema and death caused by inoculation of a massive dose of influenza B virus. Passages of influenza B virus in the presence of remantadine produced a strain causing toxicosis in mice the course of which was not affected by remantadine any longer.

UR - http://www.scopus.com/inward/record.url?scp=0019783043&partnerID=8YFLogxK

M3 - Article

C2 - 7336681

AN - SCOPUS:0019783043

VL - 26

SP - 541

EP - 543

JO - Вопросы вирусологии

JF - Вопросы вирусологии

SN - 0507-4088

IS - 5

ER -

ID: 75083966