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The effect of manganese(II) on DNA structure : Electronic and vibrational circular dichroism studies. / Polyanichko, A. M.; Andrushchenko, V. V.; Chikhirzhina, E. V.; Vorob'ev, V. I.; Wieser, H.

In: Nucleic Acids Research, Vol. 32, No. 3, 2004, p. 989-996.

Research output: Contribution to journal › Article › peer-review

Harvard

Polyanichko, AM, Andrushchenko, VV, Chikhirzhina, EV, Vorob'ev, VI & Wieser, H 2004, 'The effect of manganese(II) on DNA structure: Electronic and vibrational circular dichroism studies', Nucleic Acids Research, vol. 32, no. 3, pp. 989-996. https://doi.org/10.1093/nar/gkh242

APA

Polyanichko, A. M., Andrushchenko, V. V., Chikhirzhina, E. V., Vorob'ev, V. I., & Wieser, H. (2004). The effect of manganese(II) on DNA structure: Electronic and vibrational circular dichroism studies. Nucleic Acids Research, 32(3), 989-996. https://doi.org/10.1093/nar/gkh242

Vancouver

Polyanichko AM, Andrushchenko VV, Chikhirzhina EV, Vorob'ev VI, Wieser H. The effect of manganese(II) on DNA structure: Electronic and vibrational circular dichroism studies. Nucleic Acids Research. 2004;32(3):989-996. https://doi.org/10.1093/nar/gkh242

Author

Polyanichko, A. M. ; Andrushchenko, V. V. ; Chikhirzhina, E. V. ; Vorob'ev, V. I. ; Wieser, H. / The effect of manganese(II) on DNA structure : Electronic and vibrational circular dichroism studies. In: Nucleic Acids Research. 2004 ; Vol. 32, No. 3. pp. 989-996.

BibTeX

@article{ed5f6bf03e3a4fddb06b23d5c21b7159,
title = "The effect of manganese(II) on DNA structure: Electronic and vibrational circular dichroism studies",
abstract = "The interaction of DNA with Mn2+ was studied in absorbance and optical activity in the electronic and vibrational regions. Based on the data, several stages of the interaction were identified. Conformational transition towards the C-form of DNA was observed in solution at the molar ratio Mn2+/DNA-phosphates between 0.1 and 1.5. The exact ratio depended on the ionic strength and increased with increasing NaCl concentration. Although manganese interacted with the phosphates and bases of DNA at higher metal concentrations, it is unlikely that direct chelation occurred. A model for the interaction between manganese ions and DNA mediated by water is suggested destabilizing the double helix and partially breaking the hydrogen bonds between the base pairs. At high Mn2+ concentrations DNA aggregation was observed.",
author = "Polyanichko, {A. M.} and Andrushchenko, {V. V.} and Chikhirzhina, {E. V.} and Vorob'ev, {V. I.} and H. Wieser",
note = "Funding Information: The authors wish to acknowledge financial support from the Alberta Heritage Foundation for Medical Research (AHFMR) (Postdoctoral Fellowship to V.V.A.), the Russian Foundation for Basic Research (A.M.P., E.V.C. and V.I.V., grants 01-04-49196, 02-04-81012 Bel, 00-15-97824 and MAC 00-15-97824), and the Natural Sciences and Engineering Research Council of Canada (H.W.).",
year = "2004",
doi = "10.1093/nar/gkh242",
language = "English",
volume = "32",
pages = "989--996",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - The effect of manganese(II) on DNA structure

T2 - Electronic and vibrational circular dichroism studies

AU - Polyanichko, A. M.

AU - Andrushchenko, V. V.

AU - Chikhirzhina, E. V.

AU - Vorob'ev, V. I.

AU - Wieser, H.

N1 - Funding Information: The authors wish to acknowledge financial support from the Alberta Heritage Foundation for Medical Research (AHFMR) (Postdoctoral Fellowship to V.V.A.), the Russian Foundation for Basic Research (A.M.P., E.V.C. and V.I.V., grants 01-04-49196, 02-04-81012 Bel, 00-15-97824 and MAC 00-15-97824), and the Natural Sciences and Engineering Research Council of Canada (H.W.).

PY - 2004

Y1 - 2004

N2 - The interaction of DNA with Mn2+ was studied in absorbance and optical activity in the electronic and vibrational regions. Based on the data, several stages of the interaction were identified. Conformational transition towards the C-form of DNA was observed in solution at the molar ratio Mn2+/DNA-phosphates between 0.1 and 1.5. The exact ratio depended on the ionic strength and increased with increasing NaCl concentration. Although manganese interacted with the phosphates and bases of DNA at higher metal concentrations, it is unlikely that direct chelation occurred. A model for the interaction between manganese ions and DNA mediated by water is suggested destabilizing the double helix and partially breaking the hydrogen bonds between the base pairs. At high Mn2+ concentrations DNA aggregation was observed.

AB - The interaction of DNA with Mn2+ was studied in absorbance and optical activity in the electronic and vibrational regions. Based on the data, several stages of the interaction were identified. Conformational transition towards the C-form of DNA was observed in solution at the molar ratio Mn2+/DNA-phosphates between 0.1 and 1.5. The exact ratio depended on the ionic strength and increased with increasing NaCl concentration. Although manganese interacted with the phosphates and bases of DNA at higher metal concentrations, it is unlikely that direct chelation occurred. A model for the interaction between manganese ions and DNA mediated by water is suggested destabilizing the double helix and partially breaking the hydrogen bonds between the base pairs. At high Mn2+ concentrations DNA aggregation was observed.

UR - http://www.scopus.com/inward/record.url?scp=2342591925&partnerID=8YFLogxK

U2 - 10.1093/nar/gkh242

DO - 10.1093/nar/gkh242

M3 - Article

C2 - 14872058

AN - SCOPUS:2342591925

VL - 32

SP - 989

EP - 996

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 3

ER -

ID: 97804439