The dopamine metabolite 3-methoxytyramine is a neuromodulator. / Sotnikova, TD; Beaulieu, JM; Espinoza, S; Masri, B; Zhang, X; Salahpour, A; Barak, LS; Caron, MG; Gainetdinov, RR.
In: PLoS ONE, 2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The dopamine metabolite 3-methoxytyramine is a neuromodulator.
AU - Sotnikova, TD
AU - Beaulieu, JM
AU - Espinoza, S
AU - Masri, B
AU - Zhang, X
AU - Salahpour, A
AU - Barak, LS
AU - Caron, MG
AU - Gainetdinov, RR.
PY - 2010
Y1 - 2010
N2 - Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, 3-methoxytyramine (3-MT), can induce behavioral effects in a dopamine-independent manner and these effects are partially mediated by the trace amine associated receptor 1 (TAAR1). Unbiased in vivo screening of putative trace amine receptor ligands for potential effects on the movement control revealed that 3-MT infused in the brain is able to induce a complex set of abnormal involuntary movements in mice acutely depleted of dopamine. In normal mice, the central administration of 3-MT caused a temporary mild hyperactivity with a concomitant set of abnormal movements. Furthermore, 3-MT induced significant ERK and CREB phosphorylation in the mouse striatum, signaling events generally related to PKA-mediated cAMP accumulation. In mice lacking TAAR1, both behavioral and signaling effects of 3-MT were
AB - Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, 3-methoxytyramine (3-MT), can induce behavioral effects in a dopamine-independent manner and these effects are partially mediated by the trace amine associated receptor 1 (TAAR1). Unbiased in vivo screening of putative trace amine receptor ligands for potential effects on the movement control revealed that 3-MT infused in the brain is able to induce a complex set of abnormal involuntary movements in mice acutely depleted of dopamine. In normal mice, the central administration of 3-MT caused a temporary mild hyperactivity with a concomitant set of abnormal movements. Furthermore, 3-MT induced significant ERK and CREB phosphorylation in the mouse striatum, signaling events generally related to PKA-mediated cAMP accumulation. In mice lacking TAAR1, both behavioral and signaling effects of 3-MT were
M3 - статья
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
ER -
ID: 5573563