TY - JOUR

T1 - The digenean complex life cycle: phylostratigraphy analysis of the molecular signatures

AU - Нестеренко, Максим Алексеевич

AU - Щенков, Сергей Владимирович

AU - Денисова, Софья Александровна

AU - Старунов, Виктор Вячеславович

N1 - Publisher Copyright: © 2022 Nesterenko et al.

PY - 2022/6/24

Y1 - 2022/6/24

N2 - The parasitic flatworms from Digenea group have been the object of numerous in-depth studies for several centuries. The question of the evolutionary origin and transformation of the digenean complex life cycle remains relevant and open due to the biodiversity of these parasites and the absence of fossil records. However, modern technologies and analysis methods allow to get closer to understanding the molecular basis of both the realization of the cycle and its complication. In the present study, we have applied phylostratigraphy and evolutionary transcriptomics approaches to the available digenean genomic and transcriptomic data and built ancestral genomes models. The comparison results of Platyhelminthes and Digenea ancestor genome models made it possible to identify which genes were gained and duplicated in the possible genome of digenean ancestor. Based on the bioprocesses enrichment analysis results, we assumed that the change in the regulation of many processes, including embryogenesis, served as a basis for the complication of the ancestor life cycle. The evolutionary transcriptomics results obtained revealed the “youngest” and “oldest” life cycle stages of Fasciola gigantica, F. hepatica, Psilotrema simillimum, Schistosoma mansoni, Trichobilharzia regenti, and T. szidati. Our results can serve as a basis for a more in-depth study of the molecular signatures of life cycle stages and the evolution transformation of individual organ systems and stage-specific traits.

AB - The parasitic flatworms from Digenea group have been the object of numerous in-depth studies for several centuries. The question of the evolutionary origin and transformation of the digenean complex life cycle remains relevant and open due to the biodiversity of these parasites and the absence of fossil records. However, modern technologies and analysis methods allow to get closer to understanding the molecular basis of both the realization of the cycle and its complication. In the present study, we have applied phylostratigraphy and evolutionary transcriptomics approaches to the available digenean genomic and transcriptomic data and built ancestral genomes models. The comparison results of Platyhelminthes and Digenea ancestor genome models made it possible to identify which genes were gained and duplicated in the possible genome of digenean ancestor. Based on the bioprocesses enrichment analysis results, we assumed that the change in the regulation of many processes, including embryogenesis, served as a basis for the complication of the ancestor life cycle. The evolutionary transcriptomics results obtained revealed the “youngest” and “oldest” life cycle stages of Fasciola gigantica, F. hepatica, Psilotrema simillimum, Schistosoma mansoni, Trichobilharzia regenti, and T. szidati. Our results can serve as a basis for a more in-depth study of the molecular signatures of life cycle stages and the evolution transformation of individual organ systems and stage-specific traits.

KW - Digenea

KW - complex life cycle

KW - evolutionary transcriptomics

KW - flatworms

KW - molecular signature

KW - phylostratigraphy

UR - http://www.scopus.com/inward/record.url?scp=85140657871&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6a4a9462-c2a6-330f-a60e-4a01c8c45ec5/

U2 - https://doi.org/10.21638/spbu03.2022.201

DO - https://doi.org/10.21638/spbu03.2022.201

M3 - Article

VL - 67

SP - 65

EP - 87

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

IS - 2

ER -