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The Akt-GSK-3 signaling cascade in the actions of dopamine. / Beaulieu, Jean Martin; Gainetdinov, Raul R.; Caron, Marc G.

In: Trends in Pharmacological Sciences, Vol. 28, No. 4, 01.04.2007, p. 166-172.

Research output: Contribution to journal › Review article › peer-review

Harvard

Beaulieu, JM, Gainetdinov, RR & Caron, MG 2007, 'The Akt-GSK-3 signaling cascade in the actions of dopamine', Trends in Pharmacological Sciences, vol. 28, no. 4, pp. 166-172. https://doi.org/10.1016/j.tips.2007.02.006

APA

Beaulieu, J. M., Gainetdinov, R. R., & Caron, M. G. (2007). The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends in Pharmacological Sciences, 28(4), 166-172. https://doi.org/10.1016/j.tips.2007.02.006

Vancouver

Beaulieu JM, Gainetdinov RR, Caron MG. The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends in Pharmacological Sciences. 2007 Apr 1;28(4):166-172. https://doi.org/10.1016/j.tips.2007.02.006

Author

Beaulieu, Jean Martin ; Gainetdinov, Raul R. ; Caron, Marc G. / The Akt-GSK-3 signaling cascade in the actions of dopamine. In: Trends in Pharmacological Sciences. 2007 ; Vol. 28, No. 4. pp. 166-172.

BibTeX

@article{bcfd8f97ee054be4a29b60c6250946f9,
title = "The Akt-GSK-3 signaling cascade in the actions of dopamine",
abstract = "Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to regulate cAMP-PKA (protein kinase A) and Ca2+ pathways through G-protein-mediated signaling. However, it has become apparent that, in addition to this canonical action, D2-class dopamine receptors can function through a protein kinase B (Akt)-GSK-3 (glycogen synthase kinase 3) signaling cascade. This novel signaling mode involves the multifunctional scaffolding protein β-arrestin 2, which has a role in G-protein-coupled receptor (GPCR) desensitization. In this article, we provide an overview of how this dual function of components of the GPCR desensitization machinery relates to dopamine-receptor-mediated responses and we summarize recent insights into the relevance of the Akt-GSK-3 signaling cascade for the expression of dopamine-associated behaviors and the actions of dopaminergic drugs.",
author = "Beaulieu, {Jean Martin} and Gainetdinov, {Raul R.} and Caron, {Marc G.}",
year = "2007",
month = apr,
day = "1",
doi = "10.1016/j.tips.2007.02.006",
language = "English",
volume = "28",
pages = "166--172",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - The Akt-GSK-3 signaling cascade in the actions of dopamine

AU - Beaulieu, Jean Martin

AU - Gainetdinov, Raul R.

AU - Caron, Marc G.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to regulate cAMP-PKA (protein kinase A) and Ca2+ pathways through G-protein-mediated signaling. However, it has become apparent that, in addition to this canonical action, D2-class dopamine receptors can function through a protein kinase B (Akt)-GSK-3 (glycogen synthase kinase 3) signaling cascade. This novel signaling mode involves the multifunctional scaffolding protein β-arrestin 2, which has a role in G-protein-coupled receptor (GPCR) desensitization. In this article, we provide an overview of how this dual function of components of the GPCR desensitization machinery relates to dopamine-receptor-mediated responses and we summarize recent insights into the relevance of the Akt-GSK-3 signaling cascade for the expression of dopamine-associated behaviors and the actions of dopaminergic drugs.

AB - Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to regulate cAMP-PKA (protein kinase A) and Ca2+ pathways through G-protein-mediated signaling. However, it has become apparent that, in addition to this canonical action, D2-class dopamine receptors can function through a protein kinase B (Akt)-GSK-3 (glycogen synthase kinase 3) signaling cascade. This novel signaling mode involves the multifunctional scaffolding protein β-arrestin 2, which has a role in G-protein-coupled receptor (GPCR) desensitization. In this article, we provide an overview of how this dual function of components of the GPCR desensitization machinery relates to dopamine-receptor-mediated responses and we summarize recent insights into the relevance of the Akt-GSK-3 signaling cascade for the expression of dopamine-associated behaviors and the actions of dopaminergic drugs.

UR - http://www.scopus.com/inward/record.url?scp=33947583891&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2007.02.006

DO - 10.1016/j.tips.2007.02.006

M3 - Review article

C2 - 17349698

AN - SCOPUS:33947583891

VL - 28

SP - 166

EP - 172

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 4

ER -

ID: 36472707