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The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats. / Dorotenko, Artem; Tur, Margarita; Dolgorukova, Antonina; Bortnikov, Nikita; Belozertseva, Irina V.; Zvartau, Edwin E.; Gainetdinov, Raul R.; Sukhanov, Ilya.

In: Cellular and Molecular Neurobiology, Vol. 40, No. 2, 03.2020, p. 215-228.

Research output: Contribution to journal › Article › peer-review

Harvard

Dorotenko, A, Tur, M, Dolgorukova, A, Bortnikov, N, Belozertseva, IV, Zvartau, EE, Gainetdinov, RR & Sukhanov, I 2020, 'The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats', Cellular and Molecular Neurobiology, vol. 40, no. 2, pp. 215-228. https://doi.org/10.1007/s10571-019-00757-6

APA

Dorotenko, A., Tur, M., Dolgorukova, A., Bortnikov, N., Belozertseva, I. V., Zvartau, E. E., Gainetdinov, R. R., & Sukhanov, I. (2020). The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats. Cellular and Molecular Neurobiology, 40(2), 215-228. https://doi.org/10.1007/s10571-019-00757-6

Vancouver

Dorotenko A, Tur M, Dolgorukova A, Bortnikov N, Belozertseva IV, Zvartau EE et al. The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats. Cellular and Molecular Neurobiology. 2020 Mar;40(2): 215-228. https://doi.org/10.1007/s10571-019-00757-6

Author

Dorotenko, Artem ; Tur, Margarita ; Dolgorukova, Antonina ; Bortnikov, Nikita ; Belozertseva, Irina V. ; Zvartau, Edwin E. ; Gainetdinov, Raul R. ; Sukhanov, Ilya. / The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats. In: Cellular and Molecular Neurobiology. 2020 ; Vol. 40, No. 2. pp. 215-228.

BibTeX

@article{d304fbd3f4f24cac8163c1f417c56b21,
title = "The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats",
abstract = "Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.",
keywords = "Attention, Cognitive flexibility, Impulsivity, Rats, RO5263397, TAAR1, ACTIVATION, EFFICACY, TRACE AMINES, AMINE-ASSOCIATED RECEPTOR, SCHIZOPHRENIA, IMPULSIVITY, MONOAMINERGIC NEUROTRANSMISSION, REINFORCEMENT, AMPHETAMINE, PARADIGM",
author = "Artem Dorotenko and Margarita Tur and Antonina Dolgorukova and Nikita Bortnikov and Belozertseva, {Irina V.} and Zvartau, {Edwin E.} and Gainetdinov, {Raul R.} and Ilya Sukhanov",
year = "2020",
month = mar,
doi = "10.1007/s10571-019-00757-6",
language = "English",
volume = "40",
pages = " 215--228",
journal = "Cellular and Molecular Neurobiology",
issn = "0272-4340",
publisher = "Springer Nature",
number = "2",

}

RIS

TY - JOUR

T1 - The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats

AU - Dorotenko, Artem

AU - Tur, Margarita

AU - Dolgorukova, Antonina

AU - Bortnikov, Nikita

AU - Belozertseva, Irina V.

AU - Zvartau, Edwin E.

AU - Gainetdinov, Raul R.

AU - Sukhanov, Ilya

PY - 2020/3

Y1 - 2020/3

N2 - Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.

AB - Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.

KW - Attention

KW - Cognitive flexibility

KW - Impulsivity

KW - Rats

KW - RO5263397

KW - TAAR1

KW - ACTIVATION

KW - EFFICACY

KW - TRACE AMINES

KW - AMINE-ASSOCIATED RECEPTOR

KW - SCHIZOPHRENIA

KW - IMPULSIVITY

KW - MONOAMINERGIC NEUROTRANSMISSION

KW - REINFORCEMENT

KW - AMPHETAMINE

KW - PARADIGM

UR - http://www.scopus.com/inward/record.url?scp=85075041590&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/action-taar1-agonist-ro5263397-executive-functions-rats

UR - https://www.mendeley.com/catalogue/1b59f4ce-56bd-3401-9dfa-a654321a8215/

U2 - 10.1007/s10571-019-00757-6

DO - 10.1007/s10571-019-00757-6

M3 - Article

AN - SCOPUS:85075041590

VL - 40

SP - 215

EP - 228

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

SN - 0272-4340

IS - 2

ER -

ID: 49222614