TY - JOUR

T1 - Technetium(I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect

AU - Мирославов, Александр Евгеньевич

AU - Тюпина, Маргарита Юрьевна

AU - Сидоренко, Георгий

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Studies concerning the development of radiopharmaceuticals based on the Tc(I) carbonyl core are considered from the coordination-chemical viewpoint. The coordination behavior of the fac-Tc(CO)3+ core (hard/soft acid properties, complexation kinetics and thermodynamics, coordination preferences, mutual influence of ligands) is discussed in detail. Particular attention is paid to possible coordination isomerism and stereoisomerism of the complexes—problems that often escape from researchers’ attention. Metal-mediated ligand transformations, which can play both positive and negative role in the synthesis, are summarized for the first time. A comparative analysis of possible labeling strategies (one-pot, prelabeling, postlabeling) is made with more detailed consideration of the click-to-chelate and chelate-then-click approaches. A summary of ligands and ligand systems used for tethering the fac-Tc(CO)3+ core to biomolecules is made, including typical complexation conditions, yields, and key characteristics of the bioconjugate stability. Alternative technetium carbonyl coordination cores (higher carbonyls, mer-Tc(CO)3+, Tc(CO)2(NO)2+, Tc(CO)2(phosphine, isonitrile)2+, Tc(CO)2(isonitrile)4+) are briefly discussed. Coordination-chemical problems deserving, in authors’ opinion, a more detailed study are pointed out.

AB - Studies concerning the development of radiopharmaceuticals based on the Tc(I) carbonyl core are considered from the coordination-chemical viewpoint. The coordination behavior of the fac-Tc(CO)3+ core (hard/soft acid properties, complexation kinetics and thermodynamics, coordination preferences, mutual influence of ligands) is discussed in detail. Particular attention is paid to possible coordination isomerism and stereoisomerism of the complexes—problems that often escape from researchers’ attention. Metal-mediated ligand transformations, which can play both positive and negative role in the synthesis, are summarized for the first time. A comparative analysis of possible labeling strategies (one-pot, prelabeling, postlabeling) is made with more detailed consideration of the click-to-chelate and chelate-then-click approaches. A summary of ligands and ligand systems used for tethering the fac-Tc(CO)3+ core to biomolecules is made, including typical complexation conditions, yields, and key characteristics of the bioconjugate stability. Alternative technetium carbonyl coordination cores (higher carbonyls, mer-Tc(CO)3+, Tc(CO)2(NO)2+, Tc(CO)2(phosphine, isonitrile)2+, Tc(CO)2(isonitrile)4+) are briefly discussed. Coordination-chemical problems deserving, in authors’ opinion, a more detailed study are pointed out.

KW - Isomerism

KW - Labeling strategies

KW - Metal-mediated ligand transformations

KW - Tc bioconjugates

KW - Technetium(I) carbonyl complexes

KW - fac-Tc(CO)3+ core

UR - https://www.mendeley.com/catalogue/c347c209-47f6-3de5-a444-f002e91c85e1/

U2 - 10.1016/j.ccr.2022.214911

DO - 10.1016/j.ccr.2022.214911

M3 - Article

VL - 476

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

SN - 0010-8545

M1 - 214911

ER -