Standard

Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders. / Kalueff, A. V.; Stewart, A. M.; Nguyen, M.; Song, C.; Gottesman, I. I.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 3, No. 63, 2015, p. 76-82.

Research output: Contribution to journal › Literature review

Harvard

Kalueff, AV, Stewart, AM, Nguyen, M, Song, C & Gottesman, II 2015, 'Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders.', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 3, no. 63, pp. 76-82. https://doi.org/10.1016/j.pnpbp.2015.05.004

APA

Kalueff, A. V., Stewart, A. M., Nguyen, M., Song, C., & Gottesman, I. I. (2015). Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 3(63), 76-82. https://doi.org/10.1016/j.pnpbp.2015.05.004

Vancouver

Kalueff AV, Stewart AM, Nguyen M, Song C, Gottesman II. Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2015;3(63):76-82. https://doi.org/10.1016/j.pnpbp.2015.05.004

Author

Kalueff, A. V. ; Stewart, A. M. ; Nguyen, M. ; Song, C. ; Gottesman, I. I. / Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2015 ; Vol. 3, No. 63. pp. 76-82.

BibTeX

@article{9ad13d1abab94b248fe1e2e238d25d42,
title = "Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders.",
abstract = "One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.",
keywords = "Drug sensitivity predictor, Drug target, Efficacy, Endophenotype, Psychopharmacotherapy",
author = "Kalueff, {A. V.} and Stewart, {A. M.} and M. Nguyen and C. Song and Gottesman, {I. I.}",
year = "2015",
doi = "10.1016/j.pnpbp.2015.05.004",
language = "English",
volume = "3",
pages = "76--82",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier",
number = "63",

}

RIS

TY - JOUR

T1 - Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders.

AU - Kalueff, A. V.

AU - Stewart, A. M.

AU - Nguyen, M.

AU - Song, C.

AU - Gottesman, I. I.

PY - 2015

Y1 - 2015

N2 - One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

AB - One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

KW - Drug sensitivity predictor

KW - Drug target

KW - Efficacy

KW - Endophenotype

KW - Psychopharmacotherapy

U2 - 10.1016/j.pnpbp.2015.05.004

DO - 10.1016/j.pnpbp.2015.05.004

M3 - Literature review

VL - 3

SP - 76

EP - 82

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 63

ER -

ID: 5833123