Research output: Contribution to journal › Article › peer-review
Syringomatous structures in extramammary paget disease : A potential diagnostic pitfall. / Konstantinova, Anastasia M.; Hayes, Malcolm M.; Stewart, Colin J.R.; Plaza, Jose A.; Michal, Michal; Kerl, Katrin; Kazakov, Dmitry V.
In: American Journal of Dermatopathology, Vol. 38, No. 9, 01.09.2016, p. 653-657.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Syringomatous structures in extramammary paget disease
T2 - A potential diagnostic pitfall
AU - Konstantinova, Anastasia M.
AU - Hayes, Malcolm M.
AU - Stewart, Colin J.R.
AU - Plaza, Jose A.
AU - Michal, Michal
AU - Kerl, Katrin
AU - Kazakov, Dmitry V.
N1 - Publisher Copyright: © 2016 Wolters Kluwer Health, Inc.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. All patients were women, whose ages ranged from 49 to 93 years (median 75 years). The possible pathogenesis of the syringoma-like lesions is discussed. Awareness of these structures in vulvectomy specimens for EMPD is important to prevent misinterpretation of the syringoma-like lesions as an invasive component of the EMPD.
AB - Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. All patients were women, whose ages ranged from 49 to 93 years (median 75 years). The possible pathogenesis of the syringoma-like lesions is discussed. Awareness of these structures in vulvectomy specimens for EMPD is important to prevent misinterpretation of the syringoma-like lesions as an invasive component of the EMPD.
KW - extramammary Paget disease
KW - syringoma
KW - syringoma-like structures
KW - vulva
UR - http://www.scopus.com/inward/record.url?scp=84957837743&partnerID=8YFLogxK
U2 - 10.1097/DAD.0000000000000497
DO - 10.1097/DAD.0000000000000497
M3 - Article
C2 - 26863060
AN - SCOPUS:84957837743
VL - 38
SP - 653
EP - 657
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 9
ER -
ID: 99345985