Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives

Research output: Contribution to journal › Article › peer-review

DOI

https://doi.org/10.1134/S1070363218110178
Final published version

A series of trans-palladium(II) complexes (trans-[PdCl₂L₂], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by ¹H and ¹³C–{¹H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.

Original language	English
Pages (from-to)	2354-2358
Number of pages	5
Journal	Russian Journal of General Chemistry
Volume	88
Issue number	11
DOIs	https://doi.org/10.1134/S1070363218110178
State	Published - 1 Nov 2018

Scopus subject areas

Chemistry(all)

Research areas

antiproliferative activity, interaction with DNA, tetrazol-2-ylacetic acid derivatives, tetrazole-containing Pd(II) complexes

ID: 51239371