Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles

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Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles. / Селиверстова, Дарья Владимировна; Суслонов, Виталий Валерьевич; Zarubaev, V V; Трифонов, Ростислав Евгеньевич.

In: Russian Journal of Organic Chemistry, Vol. 54, No. 4, 04.2018, p. 633-638.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{c7e1da99155c4038ab3098b8f9019406,

title = "Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles",

abstract = "Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity.",

keywords = "1,3,4-OXADIAZOLES, AMANTADINE, BIOLOGICAL-PROPERTIES, CHEMISTRY, DERIVATIVES, INFLUENZA, TETRAZOLES, VIRUS",

author = "Селиверстова, {Дарья Владимировна} and Суслонов, {Виталий Валерьевич} and Zarubaev, {V V} and Трифонов, {Ростислав Евгеньевич}",

note = "Funding Information: This study was performed under financial support by the Russian Science Foundation (project no. 17-13-01 124).",

year = "2018",

month = apr,

doi = "10.1134/S107042801804019X",

language = "English",

volume = "54",

pages = "633--638",

journal = "Russian Journal of Organic Chemistry",

issn = "1070-4280",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "4",

}

RIS

TY - JOUR

T1 - Synthesis, Structure, and Anti-influenza Activity of 2-(Adamantan-1-yl)-5-aryl-1,3,4-oxadiazoles and 2-(Adamantan-1-yl)-5-aryltetrazoles

AU - Селиверстова, Дарья Владимировна

AU - Суслонов, Виталий Валерьевич

AU - Zarubaev, V V

AU - Трифонов, Ростислав Евгеньевич

N1 - Funding Information: This study was performed under financial support by the Russian Science Foundation (project no. 17-13-01 124).

PY - 2018/4

Y1 - 2018/4

N2 - Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity.

AB - Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity.

KW - 1,3,4-OXADIAZOLES

KW - AMANTADINE

KW - BIOLOGICAL-PROPERTIES

KW - CHEMISTRY

KW - DERIVATIVES

KW - INFLUENZA

KW - TETRAZOLES

KW - VIRUS

UR - http://www.scopus.com/inward/record.url?scp=85048148246&partnerID=8YFLogxK

U2 - 10.1134/S107042801804019X

DO - 10.1134/S107042801804019X

M3 - Article

VL - 54

SP - 633

EP - 638

JO - Russian Journal of Organic Chemistry

JF - Russian Journal of Organic Chemistry

SN - 1070-4280

IS - 4

ER -

ID: 35404377