Research output: Contribution to journal › Article › peer-review
Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis. / Zhebrun, D. A.; Totolyan, Areg A.; Maslyanskii, A. L.; Titov, A. G.; Patrukhin, A. P.; Kostareva, A. A.; Gol’tseva, I. S.
In: Bulletin of Experimental Biology and Medicine, Vol. 158, No. 2, 01.12.2014, p. 192-196.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis
AU - Zhebrun, D. A.
AU - Totolyan, Areg A.
AU - Maslyanskii, A. L.
AU - Titov, A. G.
AU - Patrukhin, A. P.
AU - Kostareva, A. A.
AU - Gol’tseva, I. S.
N1 - Publisher Copyright: © 2014, Springer Science+Business Media New York.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.
AB - We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.
KW - angiogenesis
KW - chemokines
KW - expression
KW - rheumatoid arthritis
KW - synovium
UR - http://www.scopus.com/inward/record.url?scp=84939946098&partnerID=8YFLogxK
U2 - 10.1007/s10517-014-2720-9
DO - 10.1007/s10517-014-2720-9
M3 - Article
C2 - 25430645
AN - SCOPUS:84939946098
VL - 158
SP - 192
EP - 196
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 2
ER -
ID: 93112123