• А.Р. Егоров
  • А.А. Артемьев
  • В.А. Козырев
  • Д.Н. Сикаона
  • В.В. Рубаник
  • В.В. Рубаник (мл.)
  • Илья Сергеевич Критченков
  • Н.З. Ягафаров
  • О.М. Хубиев
  • Т.А. Терешина
  • Е.К. Култышкина
  • Б. Меджбур
  • В.Н. Хрусталев
  • А.С. Критченков

Abstract: The interaction of chitosan with 3-(chloromethyl)-[1,2,4]selendiazole[4,5-a]pyridin-4 bromide results in water-soluble, selenium-containing, cationic chitosan derivatives. Derivatives of chitosan with degrees of substitution of 0.15, 0.45, and 0.65 were obtained. These derivatives are characterized by a pronounced in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli, and the antibacterial activity of the derivatives increases with an increase in their degree of substitution. The antibacterial activity of the highly substituted derivative is comparable to that of the conventional antibiotics ampicillin and gentamicin.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalApplied Biochemistry and Microbiology
Volume58
Issue number2
DOIs
StatePublished - Apr 2022

    Research areas

  • antibacterial activity, chitosan, heterocycles, selenium

    Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biochemistry

ID: 96211907