Standard

[Synthesis of GnRH analogs and their application in targeted gene delivery systems]. / Iablokova, T. V.; Chelushkin, P. S.; Dorosh, M. I.; Efremov, A. M.; Orlov, S. V.; Burov, S. V.

In: Bioorganicheskaia khimiia, Vol. 38, No. 1, 01.2012, p. 31-39.

Research output: Contribution to journal › Article › peer-review

Harvard

Iablokova, TV, Chelushkin, PS, Dorosh, MI, Efremov, AM, Orlov, SV & Burov, SV 2012, '[Synthesis of GnRH analogs and their application in targeted gene delivery systems].', Bioorganicheskaia khimiia, vol. 38, no. 1, pp. 31-39.

APA

Iablokova, T. V., Chelushkin, P. S., Dorosh, M. I., Efremov, A. M., Orlov, S. V., & Burov, S. V. (2012). [Synthesis of GnRH analogs and their application in targeted gene delivery systems]. Bioorganicheskaia khimiia, 38(1), 31-39.

Vancouver

Iablokova TV, Chelushkin PS, Dorosh MI, Efremov AM, Orlov SV, Burov SV. [Synthesis of GnRH analogs and their application in targeted gene delivery systems]. Bioorganicheskaia khimiia. 2012 Jan;38(1):31-39.

Author

Iablokova, T. V. ; Chelushkin, P. S. ; Dorosh, M. I. ; Efremov, A. M. ; Orlov, S. V. ; Burov, S. V. / [Synthesis of GnRH analogs and their application in targeted gene delivery systems]. In: Bioorganicheskaia khimiia. 2012 ; Vol. 38, No. 1. pp. 31-39.

BibTeX

@article{2b07a36b81ae421eb345bd1cceae54f1,
title = "[Synthesis of GnRH analogs and their application in targeted gene delivery systems].",
abstract = "A set of GnRH analogues containing nuclear localization signal (NLS) of SV-40 virus large T-antigen have been synthesized using solid phase peptide synthesis and chemical ligation technique. Selective chemical ligation was achieved as a result of hydrazone formation in the course of interaction between NLS hydrazide and GnRH analog modified by pyruvic acid. The efficiency of synthesized peptide carriers was demonstrated in experiments with human cancer cells transfected by reporter luciferase and beta-galactosidase genes or suicide HSV-1 thymidine kinase gene. It was shown that selectivity of action on cancer cells can be achieved as a result of peptide/DNA complex penetration through the cell membrane by GnRH receptor-mediated endocytosis pathway.",
author = "Iablokova, {T. V.} and Chelushkin, {P. S.} and Dorosh, {M. I.} and Efremov, {A. M.} and Orlov, {S. V.} and Burov, {S. V.}",
year = "2012",
month = jan,
language = "русский",
volume = "38",
pages = "31--39",
journal = "БИООРГАНИЧЕСКАЯ ХИМИЯ",
issn = "0132-3423",
publisher = "Издательство {"}Наука{"}",
number = "1",

}

RIS

TY - JOUR

T1 - [Synthesis of GnRH analogs and their application in targeted gene delivery systems].

AU - Iablokova, T. V.

AU - Chelushkin, P. S.

AU - Dorosh, M. I.

AU - Efremov, A. M.

AU - Orlov, S. V.

AU - Burov, S. V.

PY - 2012/1

Y1 - 2012/1

N2 - A set of GnRH analogues containing nuclear localization signal (NLS) of SV-40 virus large T-antigen have been synthesized using solid phase peptide synthesis and chemical ligation technique. Selective chemical ligation was achieved as a result of hydrazone formation in the course of interaction between NLS hydrazide and GnRH analog modified by pyruvic acid. The efficiency of synthesized peptide carriers was demonstrated in experiments with human cancer cells transfected by reporter luciferase and beta-galactosidase genes or suicide HSV-1 thymidine kinase gene. It was shown that selectivity of action on cancer cells can be achieved as a result of peptide/DNA complex penetration through the cell membrane by GnRH receptor-mediated endocytosis pathway.

AB - A set of GnRH analogues containing nuclear localization signal (NLS) of SV-40 virus large T-antigen have been synthesized using solid phase peptide synthesis and chemical ligation technique. Selective chemical ligation was achieved as a result of hydrazone formation in the course of interaction between NLS hydrazide and GnRH analog modified by pyruvic acid. The efficiency of synthesized peptide carriers was demonstrated in experiments with human cancer cells transfected by reporter luciferase and beta-galactosidase genes or suicide HSV-1 thymidine kinase gene. It was shown that selectivity of action on cancer cells can be achieved as a result of peptide/DNA complex penetration through the cell membrane by GnRH receptor-mediated endocytosis pathway.

UR - http://www.scopus.com/inward/record.url?scp=84866038640&partnerID=8YFLogxK

M3 - статья

C2 - 22792703

AN - SCOPUS:84866038640

VL - 38

SP - 31

EP - 39

JO - БИООРГАНИЧЕСКАЯ ХИМИЯ

JF - БИООРГАНИЧЕСКАЯ ХИМИЯ

SN - 0132-3423

IS - 1

ER -

ID: 86147072