Research output: Contribution to journal › Article › peer-review
Synthesis and studies of structure and biological properties of D-homoanalogs of steroid estrogens. / Morozkina, S.N.; Fidarov, A.F.; Mushtukov, A.S.; Selivanov, S.I.; Starova, G.L.; Shawa, A.G.
In: Russian Journal of General Chemistry, No. 10, 2013, p. 1869-1873.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Synthesis and studies of structure and biological properties of D-homoanalogs of steroid estrogens
AU - Morozkina, S.N.
AU - Fidarov, A.F.
AU - Mushtukov, A.S.
AU - Selivanov, S.I.
AU - Starova, G.L.
AU - Shawa, A.G.
PY - 2013
Y1 - 2013
N2 - In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decrease if the uterotropic action, however, the unfavorable hypertriglyceridemic effect has been retained. The latter has been eliminated by combined action of the studied steroids and ursolic acid; therewith the hypocholesterolemic activity has been retained. © 2013 Pleiades Publishing, Ltd.
AB - In order to estimate the potential of steroid estrogens modification, three D-homoanalogs of estrogens have been prepared; their structures and biological properties have been studied. The expansion of D-ring in such compounds has lead to strong decrease if the uterotropic action, however, the unfavorable hypertriglyceridemic effect has been retained. The latter has been eliminated by combined action of the studied steroids and ursolic acid; therewith the hypocholesterolemic activity has been retained. © 2013 Pleiades Publishing, Ltd.
U2 - 10.1134/S1070363213100125
DO - 10.1134/S1070363213100125
M3 - Article
SP - 1869
EP - 1873
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 10
ER -
ID: 7521925