Synthesis and pharmacological activity of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyln-acetic acids

Research output: Contribution to journal › Article › peer-review

DOI

https://doi.org/10.1007/s11094-013-0862-0
Final published version
https://doi.org/10.1007/s11094-013-0862-0
Final published version

V. A. Anisimova
A. A. Spasov
V. A. Kosolapov
I. E. Tolpygin
E. V. Tibir'Kova
O. A. Salaznikova
V. A. Kuznetsova
N. A. Gurova
K. V. Lenskaya
D. S. Yakovlev
D. V. Mal'Tsev
N. A. Kolobrodova
T. M. Mitina
O. Yu Grechko

A series of amides of 2,3-dihydroimidazo- and 2,3,4,10- tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids were synthesized. Their pharmacological activity was studied. It was established that the synthesized substances possessed antiaggregant properties and antiarrhythmic activity. Some of these amides exhibited antioxidant and hypoglycemic effects in addition to antagonist activity with respect to serotonin 5-HT₂ and purine P2Y₁ receptors.

Original language	English
Pages (from-to)	647-652
Number of pages	6
Journal	Pharmaceutical Chemistry Journal
Volume	46
Issue number	11
DOIs	https://doi.org/10.1007/s11094-013-0862-0 https://doi.org/10.1007/s11094-013-0862-0
State	Published - Feb 2013

Research areas

2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1, 2a]benzimidazoles, acetamides, antiaggregant properties, antiarrhythmic activity, antioxidant action, hypoglycemic properties, P2Y - and 5-HT-antagonist activity, synthesis

Scopus subject areas

Pharmacology
Drug Discovery

ID: 62841158