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Synthesis and medicinal applications of n-aryl-c-nitroazoles. / Chuprun, Sergey S.; Kantin, Grigory; Krasavin, Mikhail.

In: Mini-Reviews in Medicinal Chemistry, Vol. 18, No. 20, 12.11.2018, p. 1733-1752.

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Chuprun, Sergey S. ; Kantin, Grigory ; Krasavin, Mikhail. / Synthesis and medicinal applications of n-aryl-c-nitroazoles. In: Mini-Reviews in Medicinal Chemistry. 2018 ; Vol. 18, No. 20. pp. 1733-1752.

BibTeX

@article{15591d37f66043f1b9fb3b25e5579490,
title = "Synthesis and medicinal applications of n-aryl-c-nitroazoles",
abstract = "The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.",
keywords = "ANRORC, Aromatic nucleophilic substitution, Metal-catalyzed, N-arylation, Nitroazoles",
author = "Chuprun, {Sergey S.} and Grigory Kantin and Mikhail Krasavin",
year = "2018",
month = nov,
day = "12",
doi = "10.2174/1389557518666180831101841",
language = "English",
volume = "18",
pages = "1733--1752",
journal = "Mini-Reviews in Medicinal Chemistry",
issn = "1389-5575",
publisher = "Bentham Science Publishers B.V.",
number = "20",

}

RIS

TY - JOUR

T1 - Synthesis and medicinal applications of n-aryl-c-nitroazoles

AU - Chuprun, Sergey S.

AU - Kantin, Grigory

AU - Krasavin, Mikhail

PY - 2018/11/12

Y1 - 2018/11/12

N2 - The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.

AB - The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.

KW - ANRORC

KW - Aromatic nucleophilic substitution

KW - Metal-catalyzed

KW - N-arylation

KW - Nitroazoles

UR - http://www.scopus.com/inward/record.url?scp=85057438376&partnerID=8YFLogxK

UR - http://www.eurekaselect.com/165022/article

UR - http://www.mendeley.com/research/synthesis-medicinal-applications-narylcnitroazoles

U2 - 10.2174/1389557518666180831101841

DO - 10.2174/1389557518666180831101841

M3 - Review article

AN - SCOPUS:85057438376

VL - 18

SP - 1733

EP - 1752

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

SN - 1389-5575

IS - 20

ER -

ID: 36767595