Research output: Contribution to journal › Review article › peer-review
Synthesis and medicinal applications of n-aryl-c-nitroazoles. / Chuprun, Sergey S.; Kantin, Grigory; Krasavin, Mikhail.
In: Mini-Reviews in Medicinal Chemistry, Vol. 18, No. 20, 12.11.2018, p. 1733-1752.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Synthesis and medicinal applications of n-aryl-c-nitroazoles
AU - Chuprun, Sergey S.
AU - Kantin, Grigory
AU - Krasavin, Mikhail
PY - 2018/11/12
Y1 - 2018/11/12
N2 - The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.
AB - The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.
KW - ANRORC
KW - Aromatic nucleophilic substitution
KW - Metal-catalyzed
KW - N-arylation
KW - Nitroazoles
UR - http://www.scopus.com/inward/record.url?scp=85057438376&partnerID=8YFLogxK
UR - http://www.eurekaselect.com/165022/article
UR - http://www.mendeley.com/research/synthesis-medicinal-applications-narylcnitroazoles
U2 - 10.2174/1389557518666180831101841
DO - 10.2174/1389557518666180831101841
M3 - Review article
AN - SCOPUS:85057438376
VL - 18
SP - 1733
EP - 1752
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
SN - 1389-5575
IS - 20
ER -
ID: 36767595