The compound Ag₂[(UO₂)₆(MoO₄)₇(H₂O)₂](H₂O)₂ was prepared at 220°C in the course of hydrothermal synthesis. The phase crystallizes in the rhombic system, space group Pbcm, a = 14.1309(9), b = 10.6595(7), c = 25.8281(16) Å, V = 3890.44 ų. The crystal structure was solved by direct methods and refined to R ₁ = 0.049 for 4394 reflections with Fo > 4σ(Fo) and 0.1025 for all the 8239 reflections. The structure is based on a framework constituted by UO₇ and MoO₄ polyhedra sharing common vertices. In the framework, there are two systems of channels occupied by Ag⁺ cations and water molecules and oriented along [001] and [010].