TY - JOUR

T1 - Synthesis and characterization of nanocrystalline apatites from solution modeling human blood

AU - Solodyankina, Anna

AU - Nikolaev, Anton

AU - Frank-Kamenetskaya, Olga

AU - Golovanova, Olga

PY - 2016

Y1 - 2016

N2 - Present paper is devoted to the research of the calcification processes in the blood plasma of human body. Spontaneous crystallization from the solution modeling the inorganic part of the blood plasma has been carried out. Obtained precipitates were studied by the various instrumental methods (X-ray powder diffraction, Fourier-transformed infrared spectroscopy, scanning electron microscopy, electron probe microanalysis and gas-volumetric method). All gathered data allow to summarize that non-stoichiometric carbonated hydroxyapatite with low crystallinity (CSD lengths 18-28 nm), high water content and small amount of chlorine ion was obtained throughout the syntheses. Part of vacancies at the Ca sites varies from 0.17 to 0.87; the value of the Cat/(P + C) ratio from 1.52 to 1.64 (where Cat = Ca2+ + Na+ + K+ Mg2+).The poor crystallized synthetic apatites with high carbonate ion content (from 4.34 to 5.54 wt%) and c parameter (6.888-6.894 angstrom) are analogues of the apatites of the pathological cardiovascular deposits. They can be obtained from the solution modeling human blood plasma by the inorganic components with calcium phosphate supersaturation 25 and 50 and with 10 and 12 weeks experiment time. (C) 2016 Elsevier B.V. All rights reserved.

AB - Present paper is devoted to the research of the calcification processes in the blood plasma of human body. Spontaneous crystallization from the solution modeling the inorganic part of the blood plasma has been carried out. Obtained precipitates were studied by the various instrumental methods (X-ray powder diffraction, Fourier-transformed infrared spectroscopy, scanning electron microscopy, electron probe microanalysis and gas-volumetric method). All gathered data allow to summarize that non-stoichiometric carbonated hydroxyapatite with low crystallinity (CSD lengths 18-28 nm), high water content and small amount of chlorine ion was obtained throughout the syntheses. Part of vacancies at the Ca sites varies from 0.17 to 0.87; the value of the Cat/(P + C) ratio from 1.52 to 1.64 (where Cat = Ca2+ + Na+ + K+ Mg2+).The poor crystallized synthetic apatites with high carbonate ion content (from 4.34 to 5.54 wt%) and c parameter (6.888-6.894 angstrom) are analogues of the apatites of the pathological cardiovascular deposits. They can be obtained from the solution modeling human blood plasma by the inorganic components with calcium phosphate supersaturation 25 and 50 and with 10 and 12 weeks experiment time. (C) 2016 Elsevier B.V. All rights reserved.

KW - Pathological cardiovascular deposits

KW - Blood plasma

KW - Biological apatite

KW - Crystal chemistry

KW - Model experiment

KW - Biomimetic synthesis

KW - VASCULAR CALCIFICATION

KW - ATHEROSCLEROTIC PLAQUES

KW - HUMAN-BODY

KW - NANOPARTICLES

KW - PHOSPHATES

KW - DISEASE

U2 - 10.1016/j.molstruc.2016.04.080

DO - 10.1016/j.molstruc.2016.04.080

M3 - Article

VL - 1119

SP - 484

EP - 489

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

SN - 0022-2860

IS - 1119

ER -