TY - JOUR

T1 - Synthesis and characterization of macroinitiators based on polyorganophosphazenes for the ring opening polymerization of n‐carboxyanhydrides

AU - Zashikhina, Natalia

AU - Vasileva, Marina

AU - Perevedentseva, Olga

AU - Tarasenko, Irina

AU - Tennikova, Tatiana

AU - Korzhikova‐vlakh, Evgenia

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4/29

Y1 - 2021/4/29

N2 - Among the various biocompatible amphiphilic copolymers, biodegradable ones are the most promising for the preparation of drug delivery systems since they are destroyed under phys-iological conditions, that, as a rule, reduce toxicity and provide controlled release of the drug. Hybrid graft‐copolymers consisting of the main inorganic polyphosphazene chain and polypeptide side chains are of considerable interest for the development of delivery systems with a controlled degradation rate, since the main and side chains will have different degradation mechanisms (chem-ical and enzymatic hydrolysis, respectively). Variable particle degradation rate, controlled by the adjusting the composition of substituents, will allow selective delivery in vivo and controlled drug release. The present work proposes the preparation of biodegradable macroinitiators based on pol-yorganophosphazenes for the synthesis of hybrid copolymers. Synthesis of novel biodegradable macroinitiators based on polyorganophosphazenes was performed via macromolecular substitu-tion of a polydichlorophosphazene chain with the sodium alcoholates, amines and amino acids. The composition of copolymers obtained was calculated using NMR. These polyorganophosphazenes bearing primary amino groups can be considered as convenient macroinitiators for the polymerization of NCA of α‐amino acids in order to prepare hybrid copolymers polyphosphazene‐graft‐poly-peptide. The developed macroinitiators were amphiphilic and self‐assembled in the aqueous media into nanoparticles. Furthermore, the ability to encapsulate and release a model substance was demonstrated. In addition, the in vitro cytotoxicity of synthesized polymers was evaluated using two cell lines.

AB - Among the various biocompatible amphiphilic copolymers, biodegradable ones are the most promising for the preparation of drug delivery systems since they are destroyed under phys-iological conditions, that, as a rule, reduce toxicity and provide controlled release of the drug. Hybrid graft‐copolymers consisting of the main inorganic polyphosphazene chain and polypeptide side chains are of considerable interest for the development of delivery systems with a controlled degradation rate, since the main and side chains will have different degradation mechanisms (chem-ical and enzymatic hydrolysis, respectively). Variable particle degradation rate, controlled by the adjusting the composition of substituents, will allow selective delivery in vivo and controlled drug release. The present work proposes the preparation of biodegradable macroinitiators based on pol-yorganophosphazenes for the synthesis of hybrid copolymers. Synthesis of novel biodegradable macroinitiators based on polyorganophosphazenes was performed via macromolecular substitu-tion of a polydichlorophosphazene chain with the sodium alcoholates, amines and amino acids. The composition of copolymers obtained was calculated using NMR. These polyorganophosphazenes bearing primary amino groups can be considered as convenient macroinitiators for the polymerization of NCA of α‐amino acids in order to prepare hybrid copolymers polyphosphazene‐graft‐poly-peptide. The developed macroinitiators were amphiphilic and self‐assembled in the aqueous media into nanoparticles. Furthermore, the ability to encapsulate and release a model substance was demonstrated. In addition, the in vitro cytotoxicity of synthesized polymers was evaluated using two cell lines.

KW - Drug delivery systems

KW - Hybrid copolymers

KW - Macroinitiator

KW - Polyorganophosphazenes

KW - drug delivery systems

KW - HYDROGELS

KW - DESIGN

KW - PHOSPHAZENE

KW - DRUG-DELIVERY

KW - polyorganophosphazenes

KW - DOXORUBICIN

KW - RELEASE

KW - POLYPHOSPHAZENES

KW - NANOPARTICLES

KW - hybrid copolymers

KW - DEGRADATION

KW - macroinitiator

KW - POLYPEPTIDE

UR - http://www.scopus.com/inward/record.url?scp=85105778789&partnerID=8YFLogxK

U2 - 10.3390/polym13091446

DO - 10.3390/polym13091446

M3 - Article

AN - SCOPUS:85105778789

VL - 13

JO - Polymers

JF - Polymers

SN - 2073-4360

IS - 9

M1 - 1446

ER -