Standard

Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin. / Bortnevskaya, Yulia S.; Shiryaev, Nikita A.; Zakharov, Nikita S.; Kitoroage, Oleg O.; Gradova, Margarita A.; Karpechenko, Natalia Yu.; Novikov, Alexander S.; Nikolskaya, Elena D.; Mollaeva, Mariia R.; Yabbarov, Nikita G.; Bragina, Natal’ya A.; Zhdanova, Kseniya A.

In: Pharmaceutics, Vol. 15, No. 4, 1284, 19.04.2023.

Research output: Contribution to journal › Article › peer-review

Harvard

Bortnevskaya, YS, Shiryaev, NA, Zakharov, NS, Kitoroage, OO, Gradova, MA, Karpechenko, NY, Novikov, AS, Nikolskaya, ED, Mollaeva, MR, Yabbarov, NG, Bragina, NA & Zhdanova, KA 2023, 'Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin', Pharmaceutics, vol. 15, no. 4, 1284. https://doi.org/10.3390/pharmaceutics15041284

APA

Bortnevskaya, Y. S., Shiryaev, N. A., Zakharov, N. S., Kitoroage, O. O., Gradova, M. A., Karpechenko, N. Y., Novikov, A. S., Nikolskaya, E. D., Mollaeva, M. R., Yabbarov, N. G., Bragina, N. A., & Zhdanova, K. A. (2023). Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin. Pharmaceutics, 15(4), [1284]. https://doi.org/10.3390/pharmaceutics15041284

Vancouver

Bortnevskaya YS, Shiryaev NA, Zakharov NS, Kitoroage OO, Gradova MA, Karpechenko NY et al. Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin. Pharmaceutics. 2023 Apr 19;15(4). 1284. https://doi.org/10.3390/pharmaceutics15041284

Author

Bortnevskaya, Yulia S. ; Shiryaev, Nikita A. ; Zakharov, Nikita S. ; Kitoroage, Oleg O. ; Gradova, Margarita A. ; Karpechenko, Natalia Yu. ; Novikov, Alexander S. ; Nikolskaya, Elena D. ; Mollaeva, Mariia R. ; Yabbarov, Nikita G. ; Bragina, Natal’ya A. ; Zhdanova, Kseniya A. / Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin. In: Pharmaceutics. 2023 ; Vol. 15, No. 4.

BibTeX

@article{da9a06701eee4b69a4696b1f9ed5032f,
title = "Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin",
abstract = "Photodynamic therapy (PDT) in oncology is characterized by low invasiveness, minimal side effects, and little tissue scarring. Increasing the selectivity of PDT agents toward a cellular target is a new approach intended to improve this method. This study is devoted to the design and synthesis of a new conjugate based on meso-arylporphyrin with a low-molecular-weight tyrosine kinase inhibitor, Erlotinib. A nano-formulation based on Pluronic F127 micelles was obtained and characterized. The photophysical and photochemical properties and biological activity of the studied compounds and their nano-formulation were studied. A significant, 20-40-fold difference between the dark and photoinduced activity was achieved for the conjugate nanomicelles. After irradiation, the studied conjugate nanomicelles were 1.8 times more toxic toward the EGFR-overexpressing cell line MDA-MB-231 compared to the conditionally normal NKE cells. The IC50 was 0.073 ± 0.014 μM for the MDA-MB-231 cell line and 0.13 ± 0.018 μM for NKE cells after irradiation for the target conjugate nanomicelles.",
keywords = "PDT, Pluronic F127, antitumor efficacy, conjugates, erlotinib, meso-arylporphyrins, nano-formulation, polymer nanomicelles, porphyrin metal complexes",
author = "Bortnevskaya, {Yulia S.} and Shiryaev, {Nikita A.} and Zakharov, {Nikita S.} and Kitoroage, {Oleg O.} and Gradova, {Margarita A.} and Karpechenko, {Natalia Yu.} and Novikov, {Alexander S.} and Nikolskaya, {Elena D.} and Mollaeva, {Mariia R.} and Yabbarov, {Nikita G.} and Bragina, {Natal{\textquoteright}ya A.} and Zhdanova, {Kseniya A.}",
year = "2023",
month = apr,
day = "19",
doi = "10.3390/pharmaceutics15041284",
language = "English",
volume = "15",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin

AU - Bortnevskaya, Yulia S.

AU - Shiryaev, Nikita A.

AU - Zakharov, Nikita S.

AU - Kitoroage, Oleg O.

AU - Gradova, Margarita A.

AU - Karpechenko, Natalia Yu.

AU - Novikov, Alexander S.

AU - Nikolskaya, Elena D.

AU - Mollaeva, Mariia R.

AU - Yabbarov, Nikita G.

AU - Bragina, Natal’ya A.

AU - Zhdanova, Kseniya A.

PY - 2023/4/19

Y1 - 2023/4/19

N2 - Photodynamic therapy (PDT) in oncology is characterized by low invasiveness, minimal side effects, and little tissue scarring. Increasing the selectivity of PDT agents toward a cellular target is a new approach intended to improve this method. This study is devoted to the design and synthesis of a new conjugate based on meso-arylporphyrin with a low-molecular-weight tyrosine kinase inhibitor, Erlotinib. A nano-formulation based on Pluronic F127 micelles was obtained and characterized. The photophysical and photochemical properties and biological activity of the studied compounds and their nano-formulation were studied. A significant, 20-40-fold difference between the dark and photoinduced activity was achieved for the conjugate nanomicelles. After irradiation, the studied conjugate nanomicelles were 1.8 times more toxic toward the EGFR-overexpressing cell line MDA-MB-231 compared to the conditionally normal NKE cells. The IC50 was 0.073 ± 0.014 μM for the MDA-MB-231 cell line and 0.13 ± 0.018 μM for NKE cells after irradiation for the target conjugate nanomicelles.

AB - Photodynamic therapy (PDT) in oncology is characterized by low invasiveness, minimal side effects, and little tissue scarring. Increasing the selectivity of PDT agents toward a cellular target is a new approach intended to improve this method. This study is devoted to the design and synthesis of a new conjugate based on meso-arylporphyrin with a low-molecular-weight tyrosine kinase inhibitor, Erlotinib. A nano-formulation based on Pluronic F127 micelles was obtained and characterized. The photophysical and photochemical properties and biological activity of the studied compounds and their nano-formulation were studied. A significant, 20-40-fold difference between the dark and photoinduced activity was achieved for the conjugate nanomicelles. After irradiation, the studied conjugate nanomicelles were 1.8 times more toxic toward the EGFR-overexpressing cell line MDA-MB-231 compared to the conditionally normal NKE cells. The IC50 was 0.073 ± 0.014 μM for the MDA-MB-231 cell line and 0.13 ± 0.018 μM for NKE cells after irradiation for the target conjugate nanomicelles.

KW - PDT

KW - Pluronic F127

KW - antitumor efficacy

KW - conjugates

KW - erlotinib

KW - meso-arylporphyrins

KW - nano-formulation

KW - polymer nanomicelles

KW - porphyrin metal complexes

UR - https://www.mendeley.com/catalogue/668279f3-3885-34ec-85b1-703ff144c21d/

U2 - 10.3390/pharmaceutics15041284

DO - 10.3390/pharmaceutics15041284

M3 - Article

C2 - 37111769

VL - 15

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 4

M1 - 1284

ER -

ID: 104537765