Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety

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Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety. / Popova, E.A.; Trifonov, R.E.

In: Russian Chemical Reviews, Vol. 84, No. 9, 2015, p. 891-916.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{4e4aa30d6b60489393122fd9764a4d56,

title = "Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety",

abstract = "Literature data published mainly in the last 15 years on the synthesis and biological properties of amino acid analogues andderivatives containing tetrazolyl moieties are analyzed. Tetrazolyl analogues and derivatives of amino acids and peptides areshown to be promising for medicinal chemistry. Being polynitrogen heterocyclic systems comprising four endocyclic nitrogenatoms, tetrazoles can behave as acids and bases and form strong hydrogen bonds with proton donors (more rarely, withacceptors). They have high metabolic stability and are able to penetrate biological membranes. The review also considers thesynthesis and properties of linear and cyclic peptides based on modified amino acids incorporating a tetrazolyl moiety. Aspecial issue is the discussion of the biological properties of tetrazole-containing amino acids and peptides, which exhibit highbiological activity and can be used to design new drugs.The bibliography includes 200 references.",

author = "E.A. Popova and R.E. Trifonov",

year = "2015",

doi = "10.1070/RCR4527",

language = "English",

volume = "84",

pages = "891--916",

journal = "Russian Chemical Reviews",

issn = "0036-021X",

publisher = "Turpion Ltd.",

number = "9",

}

RIS

TY - JOUR

T1 - Synthesis and biological properties of amino acids and peptides containing a tetrazolyl moiety

AU - Popova, E.A.

AU - Trifonov, R.E.

PY - 2015

Y1 - 2015

N2 - Literature data published mainly in the last 15 years on the synthesis and biological properties of amino acid analogues andderivatives containing tetrazolyl moieties are analyzed. Tetrazolyl analogues and derivatives of amino acids and peptides areshown to be promising for medicinal chemistry. Being polynitrogen heterocyclic systems comprising four endocyclic nitrogenatoms, tetrazoles can behave as acids and bases and form strong hydrogen bonds with proton donors (more rarely, withacceptors). They have high metabolic stability and are able to penetrate biological membranes. The review also considers thesynthesis and properties of linear and cyclic peptides based on modified amino acids incorporating a tetrazolyl moiety. Aspecial issue is the discussion of the biological properties of tetrazole-containing amino acids and peptides, which exhibit highbiological activity and can be used to design new drugs.The bibliography includes 200 references.

AB - Literature data published mainly in the last 15 years on the synthesis and biological properties of amino acid analogues andderivatives containing tetrazolyl moieties are analyzed. Tetrazolyl analogues and derivatives of amino acids and peptides areshown to be promising for medicinal chemistry. Being polynitrogen heterocyclic systems comprising four endocyclic nitrogenatoms, tetrazoles can behave as acids and bases and form strong hydrogen bonds with proton donors (more rarely, withacceptors). They have high metabolic stability and are able to penetrate biological membranes. The review also considers thesynthesis and properties of linear and cyclic peptides based on modified amino acids incorporating a tetrazolyl moiety. Aspecial issue is the discussion of the biological properties of tetrazole-containing amino acids and peptides, which exhibit highbiological activity and can be used to design new drugs.The bibliography includes 200 references.

U2 - 10.1070/RCR4527

DO - 10.1070/RCR4527

M3 - Review article

VL - 84

SP - 891

EP - 916

JO - Russian Chemical Reviews

JF - Russian Chemical Reviews

SN - 0036-021X

IS - 9

ER -

ID: 3988162