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Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens. / Morozkina, S.N.; Abusalimov, Sh.N.; Selivanov, S.I.; Shavva, A.G.

In: Russian Journal of Organic Chemistry, Vol. 49, No. 4, 2013, p. 603-609.

Research output: Contribution to journal › Article

Harvard

Morozkina, SN, Abusalimov, SN, Selivanov, SI & Shavva, AG 2013, 'Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens', Russian Journal of Organic Chemistry, vol. 49, no. 4, pp. 603-609. https://doi.org/10.1134/S1070428013040180

APA

Morozkina, S. N., Abusalimov, S. N., Selivanov, S. I., & Shavva, A. G. (2013). Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens. Russian Journal of Organic Chemistry, 49(4), 603-609. https://doi.org/10.1134/S1070428013040180

Vancouver

Morozkina SN, Abusalimov SN, Selivanov SI, Shavva AG. Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens. Russian Journal of Organic Chemistry. 2013;49(4):603-609. https://doi.org/10.1134/S1070428013040180

Author

Morozkina, S.N. ; Abusalimov, Sh.N. ; Selivanov, S.I. ; Shavva, A.G. / Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens. In: Russian Journal of Organic Chemistry. 2013 ; Vol. 49, No. 4. pp. 603-609.

BibTeX

@article{c536bde99ed0451db32ffe661d31e9d2,
title = "Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens",
abstract = "8 alpha-Analogs of steroidal estrogens containing a methyl group on C-1 or an oxo group on C-6 were synthesized with a view to obtain compounds exhibiting selective biological activity, and their steric structure was studied. As shown with 1,3-O-dimethyl-8 alpha-estrone as an example, such compounds in solution can exist as two conformers, whereas the oxo group on C-6 almost does not affect conformation of the modified derivative as compared to the parent structure. Some newly synthesized compounds exhibited hypocholesterolemic activity in combination with reduced uterotropic effect, which is important for the design of drugs for the treatment of atherosclerosis. 6-Oxo-8 alpha-analogs showed osteoprotective activity, so that introduction of an oxo group into the 6-position is promising from the viewpoint of hormone replacement therapy.",
author = "S.N. Morozkina and Sh.N. Abusalimov and S.I. Selivanov and A.G. Shavva",
year = "2013",
doi = "10.1134/S1070428013040180",
language = "English",
volume = "49",
pages = "603--609",
journal = "Russian Journal of Organic Chemistry",
issn = "1070-4280",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "4",

}

RIS

TY - JOUR

T1 - Synthesis and biological activity of some 8 alpha-analogs of steroidal estrogens

AU - Morozkina, S.N.

AU - Abusalimov, Sh.N.

AU - Selivanov, S.I.

AU - Shavva, A.G.

PY - 2013

Y1 - 2013

N2 - 8 alpha-Analogs of steroidal estrogens containing a methyl group on C-1 or an oxo group on C-6 were synthesized with a view to obtain compounds exhibiting selective biological activity, and their steric structure was studied. As shown with 1,3-O-dimethyl-8 alpha-estrone as an example, such compounds in solution can exist as two conformers, whereas the oxo group on C-6 almost does not affect conformation of the modified derivative as compared to the parent structure. Some newly synthesized compounds exhibited hypocholesterolemic activity in combination with reduced uterotropic effect, which is important for the design of drugs for the treatment of atherosclerosis. 6-Oxo-8 alpha-analogs showed osteoprotective activity, so that introduction of an oxo group into the 6-position is promising from the viewpoint of hormone replacement therapy.

AB - 8 alpha-Analogs of steroidal estrogens containing a methyl group on C-1 or an oxo group on C-6 were synthesized with a view to obtain compounds exhibiting selective biological activity, and their steric structure was studied. As shown with 1,3-O-dimethyl-8 alpha-estrone as an example, such compounds in solution can exist as two conformers, whereas the oxo group on C-6 almost does not affect conformation of the modified derivative as compared to the parent structure. Some newly synthesized compounds exhibited hypocholesterolemic activity in combination with reduced uterotropic effect, which is important for the design of drugs for the treatment of atherosclerosis. 6-Oxo-8 alpha-analogs showed osteoprotective activity, so that introduction of an oxo group into the 6-position is promising from the viewpoint of hormone replacement therapy.

U2 - 10.1134/S1070428013040180

DO - 10.1134/S1070428013040180

M3 - Article

VL - 49

SP - 603

EP - 609

JO - Russian Journal of Organic Chemistry

JF - Russian Journal of Organic Chemistry

SN - 1070-4280

IS - 4

ER -

ID: 7521958