Standard

Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts. / Gein, V. L.; Bobrovskaya, O. V.; Russkikh, A. A.; Novikova, V. V.; Gein, O. N.; Karpenko, Yu. N.; Chashchina, S. V.; Dmitriev, M. V.; Yankin, A. N.

In: Russian Journal of General Chemistry, Vol. 89, No. 4, 01.04.2019, p. 680-688.

Research output: Contribution to journal › Article › peer-review

Harvard

Gein, VL, Bobrovskaya, OV, Russkikh, AA, Novikova, VV, Gein, ON, Karpenko, YN, Chashchina, SV, Dmitriev, MV & Yankin, AN 2019, 'Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts', Russian Journal of General Chemistry, vol. 89, no. 4, pp. 680-688. https://doi.org/10.1134/S1070363219040078

APA

Gein, V. L., Bobrovskaya, O. V., Russkikh, A. A., Novikova, V. V., Gein, O. N., Karpenko, Y. N., Chashchina, S. V., Dmitriev, M. V., & Yankin, A. N. (2019). Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts. Russian Journal of General Chemistry, 89(4), 680-688. https://doi.org/10.1134/S1070363219040078

Vancouver

Gein VL, Bobrovskaya OV, Russkikh AA, Novikova VV, Gein ON, Karpenko YN et al. Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts. Russian Journal of General Chemistry. 2019 Apr 1;89(4):680-688. https://doi.org/10.1134/S1070363219040078

Author

Gein, V. L. ; Bobrovskaya, O. V. ; Russkikh, A. A. ; Novikova, V. V. ; Gein, O. N. ; Karpenko, Yu. N. ; Chashchina, S. V. ; Dmitriev, M. V. ; Yankin, A. N. / Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts. In: Russian Journal of General Chemistry. 2019 ; Vol. 89, No. 4. pp. 680-688.

BibTeX

@article{366f68420f8040668249f2295c9e59ca,
title = "Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts",
abstract = "The reaction of 4-aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.",
keywords = "analgesic activity, anti-inflammatory activity, antimicrobial activity, pyrazole-3-carboxamide silver and sodium salts, pyrazole-3-carboxamides",
author = "Gein, {V. L.} and Bobrovskaya, {O. V.} and Russkikh, {A. A.} and Novikova, {V. V.} and Gein, {O. N.} and Karpenko, {Yu. N.} and Chashchina, {S. V.} and Dmitriev, {M. V.} and Yankin, {A. N.}",
year = "2019",
month = apr,
day = "1",
doi = "10.1134/S1070363219040078",
language = "English",
volume = "89",
pages = "680--688",
journal = "Russian Journal of General Chemistry",
issn = "1070-3632",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "4",

}

RIS

TY - JOUR

T1 - Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts

AU - Gein, V. L.

AU - Bobrovskaya, O. V.

AU - Russkikh, A. A.

AU - Novikova, V. V.

AU - Gein, O. N.

AU - Karpenko, Yu. N.

AU - Chashchina, S. V.

AU - Dmitriev, M. V.

AU - Yankin, A. N.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The reaction of 4-aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.

AB - The reaction of 4-aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.

KW - analgesic activity

KW - anti-inflammatory activity

KW - antimicrobial activity

KW - pyrazole-3-carboxamide silver and sodium salts

KW - pyrazole-3-carboxamides

UR - http://www.scopus.com/inward/record.url?scp=85066234283&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/synthesis-biological-activity-5aryln413thiazol2ylsulfamoylphenyl1phenyl1hpyrazole3carboxamides-salts

U2 - 10.1134/S1070363219040078

DO - 10.1134/S1070363219040078

M3 - Article

AN - SCOPUS:85066234283

VL - 89

SP - 680

EP - 688

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - 4

ER -

ID: 45307342