Research output: Contribution to journal › Article › peer-review
Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts. / Gein, V. L.; Bobrovskaya, O. V.; Russkikh, A. A.; Novikova, V. V.; Gein, O. N.; Karpenko, Yu. N.; Chashchina, S. V.; Dmitriev, M. V.; Yankin, A. N.
In: Russian Journal of General Chemistry, Vol. 89, No. 4, 01.04.2019, p. 680-688.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts
AU - Gein, V. L.
AU - Bobrovskaya, O. V.
AU - Russkikh, A. A.
AU - Novikova, V. V.
AU - Gein, O. N.
AU - Karpenko, Yu. N.
AU - Chashchina, S. V.
AU - Dmitriev, M. V.
AU - Yankin, A. N.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - The reaction of 4-aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.
AB - The reaction of 4-aryl-2-hydroxy-4-oxo-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}but-2-enamides with phenylhydrazine in glacial acetic acid afforded 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides. Treatment of the latter with an equimolar amount of silver nitrate in ethanol–DMF (2:1) gave the corresponding silver salts, while 5-aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamide sodium salts were obtained by reaction with sodium methoxide in methanol–DMF (1:1). The synthesized compounds were tested for analgesic, anti-inflammatory, and antimicrobial activities.
KW - analgesic activity
KW - anti-inflammatory activity
KW - antimicrobial activity
KW - pyrazole-3-carboxamide silver and sodium salts
KW - pyrazole-3-carboxamides
UR - http://www.scopus.com/inward/record.url?scp=85066234283&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/synthesis-biological-activity-5aryln413thiazol2ylsulfamoylphenyl1phenyl1hpyrazole3carboxamides-salts
U2 - 10.1134/S1070363219040078
DO - 10.1134/S1070363219040078
M3 - Article
AN - SCOPUS:85066234283
VL - 89
SP - 680
EP - 688
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 4
ER -
ID: 45307342