A new reticulate hernioprosthesis has been developed and proposed for clinical use. The adhesive high molecular polymer coating containing silver nanoclusters was applied on the lavsan network. After implantation the polymer was dissolved in the tissue fluid and formed the hollows between the threads facilitating invasion of the connective tissue into the network. The prolonged antimicrobial effect was proved to stay in the wound tissue as long as 5 days. Silver nanoclusters prevent the formation of microbial biofilms and development of suppuration around the prosthesis. Its unique properties are confirmed by positive results of its clinical use.