Standard

Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m. / Gorshkov, N. I.; Miroslavov, A. E.; Аlekseev, I. E.; Lumpov, A. A.; Мurko, A. Y.; Gavrilova, I. I.; Saprykina, N. N.; Bezrukova, M. A.; Kipper, A. I.; Krasikov, V. D.; Suglobov, D. N.; Tyupina, M. Y.; Panarin, E. F.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 60, No. 6, 30.05.2017, p. 302-311.

Research output: Contribution to journal › Article › peer-review

Harvard

Gorshkov, NI, Miroslavov, AE, Аlekseev, IE, Lumpov, AA, Мurko, AY, Gavrilova, II, Saprykina, NN, Bezrukova, MA, Kipper, AI, Krasikov, VD, Suglobov, DN, Tyupina, MY & Panarin, EF 2017, 'Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 6, pp. 302-311. https://doi.org/10.1002/jlcr.3503, https://doi.org/10.1002/jlcr.3503

APA

Gorshkov, N. I., Miroslavov, A. E., Аlekseev, I. E., Lumpov, A. A., Мurko, A. Y., Gavrilova, I. I., Saprykina, N. N., Bezrukova, M. A., Kipper, A. I., Krasikov, V. D., Suglobov, D. N., Tyupina, M. Y., & Panarin, E. F. (2017). Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m. Journal of Labelled Compounds and Radiopharmaceuticals, 60(6), 302-311. https://doi.org/10.1002/jlcr.3503, https://doi.org/10.1002/jlcr.3503

Vancouver

Gorshkov NI, Miroslavov AE, Аlekseev IE, Lumpov AA, Мurko AY, Gavrilova II et al. Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m. Journal of Labelled Compounds and Radiopharmaceuticals. 2017 May 30;60(6):302-311. https://doi.org/10.1002/jlcr.3503, https://doi.org/10.1002/jlcr.3503

Author

Gorshkov, N. I. ; Miroslavov, A. E. ; Аlekseev, I. E. ; Lumpov, A. A. ; Мurko, A. Y. ; Gavrilova, I. I. ; Saprykina, N. N. ; Bezrukova, M. A. ; Kipper, A. I. ; Krasikov, V. D. ; Suglobov, D. N. ; Tyupina, M. Y. ; Panarin, E. F. / Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2017 ; Vol. 60, No. 6. pp. 302-311.

BibTeX

@article{4971a822060640c5b1770f2fad085e81,
title = "Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m",
abstract = "The procedure of the directed synthesis of N-vinylpyrrolidone-N-vinylformamide (VP-VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium-113m were developed. The metal-copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high-performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium-113m were optimized. It was shown that the VP-VFA-IDA copolymer firmly binds indium-113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP-VFA-IDA-In conjugates were found to be unstable in histidine challenge reaction.",
keywords = "bioconjugates, indium-113m, labelling, N-vinylpyrrolidone-N-vinylformamide copolymer, radiochemical synthesis, site specific radiopharmaceuticals",
author = "Gorshkov, {N. I.} and Miroslavov, {A. E.} and Аlekseev, {I. E.} and Lumpov, {A. A.} and Мurko, {A. Y.} and Gavrilova, {I. I.} and Saprykina, {N. N.} and Bezrukova, {M. A.} and Kipper, {A. I.} and Krasikov, {V. D.} and Suglobov, {D. N.} and Tyupina, {M. Y.} and Panarin, {E. F.}",
note = "Funding Information: The study was financially supported by the Russian Foundation for Basic Researches (Projects no. 15-03-04170a and 16-03-00584). Publisher Copyright: Copyright {\textcopyright} 2017 John Wiley & Sons, Ltd. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2017",
month = may,
day = "30",
doi = "10.1002/jlcr.3503",
language = "English",
volume = "60",
pages = "302--311",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m

AU - Gorshkov, N. I.

AU - Miroslavov, A. E.

AU - Аlekseev, I. E.

AU - Lumpov, A. A.

AU - Мurko, A. Y.

AU - Gavrilova, I. I.

AU - Saprykina, N. N.

AU - Bezrukova, M. A.

AU - Kipper, A. I.

AU - Krasikov, V. D.

AU - Suglobov, D. N.

AU - Tyupina, M. Y.

AU - Panarin, E. F.

N1 - Funding Information: The study was financially supported by the Russian Foundation for Basic Researches (Projects no. 15-03-04170a and 16-03-00584). Publisher Copyright: Copyright © 2017 John Wiley & Sons, Ltd. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/5/30

Y1 - 2017/5/30

N2 - The procedure of the directed synthesis of N-vinylpyrrolidone-N-vinylformamide (VP-VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium-113m were developed. The metal-copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high-performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium-113m were optimized. It was shown that the VP-VFA-IDA copolymer firmly binds indium-113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP-VFA-IDA-In conjugates were found to be unstable in histidine challenge reaction.

AB - The procedure of the directed synthesis of N-vinylpyrrolidone-N-vinylformamide (VP-VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium-113m were developed. The metal-copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high-performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium-113m were optimized. It was shown that the VP-VFA-IDA copolymer firmly binds indium-113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP-VFA-IDA-In conjugates were found to be unstable in histidine challenge reaction.

KW - bioconjugates

KW - indium-113m

KW - labelling

KW - N-vinylpyrrolidone-N-vinylformamide copolymer

KW - radiochemical synthesis

KW - site specific radiopharmaceuticals

UR - http://www.scopus.com/inward/record.url?scp=85019740448&partnerID=8YFLogxK

U2 - 10.1002/jlcr.3503

DO - 10.1002/jlcr.3503

M3 - Article

C2 - 28349626

AN - SCOPUS:85019740448

VL - 60

SP - 302

EP - 311

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 6

ER -

ID: 42885590