Studies of DNA interaction with coordination compounds of the divalent platinum. II. Effect of type and position of ligands from the first coordination sphere of platinum

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Studies of DNA interaction with coordination compounds of the divalent platinum. II. Effect of type and position of ligands from the first coordination sphere of platinum. / Kasyanenko, N. A.; Karymov, M. A.; Dyachenko, S. A.; Smorygo, N. A.; Frisman, E. V.

In: Molekulyarnaya Biologiya, Vol. 29, No. 3, 1995, p. 585-596.

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BibTeX

@article{0faa5684bd4445108add7f54e0e285c9,

title = "Studies of DNA interaction with coordination compounds of the divalent platinum. II. Effect of type and position of ligands from the first coordination sphere of platinum",

abstract = "The interaction of DNA molecule with some coordination compounds of the divalent platinum: cis-DDP, trans-DDP, [(NH3)4Pt]Cl2 and K2PtCl4 was studied. It was shown that the transition of the cis-DDP, trans-DDP, and [PtCl4]2- to aquo-complexes is necessary for their binding with DNA in solution. It was shown that the labile chloride groups are responsible for the formation of the energetically strong binding. The distance between chloride groups in cis-DDP is optimal for incorporation of two groups of DNA bases into the first coordination sphere of platinum. The complexes are also stabilized with phosphate in the external coordination sphere of platinum. The sterical non-conformity between the DNA structure and positions of chloride groups and the orientation of the amino groups in trans-DDP are the main obstructions for the formation of bidentate DNA-trans-DDP complexes. The existence of more that two vacant positions for binding with DNA in [PtCl4]2- does not stabilise the complex. The compound [(NH3)4Pt]Cl2 cannot produce coordination bonds with DNA, because its first coordination sphere is completed with amino groups; it interacts with DNA, forming principally different complexes.",

author = "Kasyanenko, {N. A.} and Karymov, {M. A.} and Dyachenko, {S. A.} and Smorygo, {N. A.} and Frisman, {E. V.}",

year = "1995",

language = "English",

volume = "29",

pages = "585--596",

journal = "МОЛЕКУЛЯРНАЯ БИОЛОГИЯ",

issn = "0026-8984",

publisher = "Российская академия наук",

number = "3",

}

RIS

TY - JOUR

T1 - Studies of DNA interaction with coordination compounds of the divalent platinum. II. Effect of type and position of ligands from the first coordination sphere of platinum

AU - Kasyanenko, N. A.

AU - Karymov, M. A.

AU - Dyachenko, S. A.

AU - Smorygo, N. A.

AU - Frisman, E. V.

PY - 1995

Y1 - 1995

N2 - The interaction of DNA molecule with some coordination compounds of the divalent platinum: cis-DDP, trans-DDP, [(NH3)4Pt]Cl2 and K2PtCl4 was studied. It was shown that the transition of the cis-DDP, trans-DDP, and [PtCl4]2- to aquo-complexes is necessary for their binding with DNA in solution. It was shown that the labile chloride groups are responsible for the formation of the energetically strong binding. The distance between chloride groups in cis-DDP is optimal for incorporation of two groups of DNA bases into the first coordination sphere of platinum. The complexes are also stabilized with phosphate in the external coordination sphere of platinum. The sterical non-conformity between the DNA structure and positions of chloride groups and the orientation of the amino groups in trans-DDP are the main obstructions for the formation of bidentate DNA-trans-DDP complexes. The existence of more that two vacant positions for binding with DNA in [PtCl4]2- does not stabilise the complex. The compound [(NH3)4Pt]Cl2 cannot produce coordination bonds with DNA, because its first coordination sphere is completed with amino groups; it interacts with DNA, forming principally different complexes.

AB - The interaction of DNA molecule with some coordination compounds of the divalent platinum: cis-DDP, trans-DDP, [(NH3)4Pt]Cl2 and K2PtCl4 was studied. It was shown that the transition of the cis-DDP, trans-DDP, and [PtCl4]2- to aquo-complexes is necessary for their binding with DNA in solution. It was shown that the labile chloride groups are responsible for the formation of the energetically strong binding. The distance between chloride groups in cis-DDP is optimal for incorporation of two groups of DNA bases into the first coordination sphere of platinum. The complexes are also stabilized with phosphate in the external coordination sphere of platinum. The sterical non-conformity between the DNA structure and positions of chloride groups and the orientation of the amino groups in trans-DDP are the main obstructions for the formation of bidentate DNA-trans-DDP complexes. The existence of more that two vacant positions for binding with DNA in [PtCl4]2- does not stabilise the complex. The compound [(NH3)4Pt]Cl2 cannot produce coordination bonds with DNA, because its first coordination sphere is completed with amino groups; it interacts with DNA, forming principally different complexes.

UR - http://www.scopus.com/inward/record.url?scp=0029553988&partnerID=8YFLogxK

M3 - Article

C2 - 8552062

AN - SCOPUS:0029553988

VL - 29

SP - 585

EP - 596

JO - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

JF - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

SN - 0026-8984

IS - 3

ER -

ID: 73393978