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Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters. / Kasyanenko, N. A.; Valueva, S. V.; Smorygo, N. A.; Dyachenko, S. A.; Frisman, E. V.

In: Molekulyarnaya Biologiya, Vol. 29, No. 2, 1995, p. 345-353.

Research output: Contribution to journal › Article › peer-review

Harvard

Kasyanenko, NA, Valueva, SV, Smorygo, NA, Dyachenko, SA & Frisman, EV 1995, 'Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters', Molekulyarnaya Biologiya, vol. 29, no. 2, pp. 345-353.

APA

Kasyanenko, N. A., Valueva, S. V., Smorygo, N. A., Dyachenko, S. A., & Frisman, E. V. (1995). Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters. Molekulyarnaya Biologiya, 29(2), 345-353.

Vancouver

Kasyanenko NA, Valueva SV, Smorygo NA, Dyachenko SA, Frisman EV. Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters. Molekulyarnaya Biologiya. 1995;29(2):345-353.

Author

Kasyanenko, N. A. ; Valueva, S. V. ; Smorygo, N. A. ; Dyachenko, S. A. ; Frisman, E. V. / Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters. In: Molekulyarnaya Biologiya. 1995 ; Vol. 29, No. 2. pp. 345-353.

BibTeX

@article{376c1d6b5935413cb3d4797dba5d5283,
title = "Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters",
abstract = "DNA interaction with cis-diamindicloroplatinum (cis-DDP) in solutions of different ionic strength was studied by flow birefringence, viscometry, circular dichroism. Though cis-DDP is not an electrolyte, electrostatic interactions are important for binding of cis-DDP with DNA probably for transporting cis-DDP to a macromolecule. The charges aqua-complex is formed by cis-DDP. The complexation being dependent on the platinum/DNA ratio in solution. Along with the increase of platinum concentration, it forms first the complexes with phosphate groups, then with bases without destruction of the DNA secondary structure. The next type of complex formation is accompanied by the local destruction of the hydrogen bonds and stacking interactions. And when the Pt/DNA ratio grows high enough, DNA is denatured. It is suggested that the stability of the complex is provided by nitrogen groups of the bases incorporated in the platinum first coordination sphere. The phosphate DNA groups play the role of counterions in the external coordination sphere.",
author = "Kasyanenko, {N. A.} and Valueva, {S. V.} and Smorygo, {N. A.} and Dyachenko, {S. A.} and Frisman, {E. V.}",
note = "Copyright: Copyright 2004 Elsevier B.V., All rights reserved.",
year = "1995",
language = "English",
volume = "29",
pages = "345--353",
journal = "МОЛЕКУЛЯРНАЯ БИОЛОГИЯ",
issn = "0026-8984",
publisher = "Российская академия наук",
number = "2",

}

RIS

TY - JOUR

T1 - Studies of DNA interaction with coordination compounds of the divalent platinum. I. Effect of cis-diamindichloroplatinum on DNA molecular parameters

AU - Kasyanenko, N. A.

AU - Valueva, S. V.

AU - Smorygo, N. A.

AU - Dyachenko, S. A.

AU - Frisman, E. V.

N1 - Copyright: Copyright 2004 Elsevier B.V., All rights reserved.

PY - 1995

Y1 - 1995

N2 - DNA interaction with cis-diamindicloroplatinum (cis-DDP) in solutions of different ionic strength was studied by flow birefringence, viscometry, circular dichroism. Though cis-DDP is not an electrolyte, electrostatic interactions are important for binding of cis-DDP with DNA probably for transporting cis-DDP to a macromolecule. The charges aqua-complex is formed by cis-DDP. The complexation being dependent on the platinum/DNA ratio in solution. Along with the increase of platinum concentration, it forms first the complexes with phosphate groups, then with bases without destruction of the DNA secondary structure. The next type of complex formation is accompanied by the local destruction of the hydrogen bonds and stacking interactions. And when the Pt/DNA ratio grows high enough, DNA is denatured. It is suggested that the stability of the complex is provided by nitrogen groups of the bases incorporated in the platinum first coordination sphere. The phosphate DNA groups play the role of counterions in the external coordination sphere.

AB - DNA interaction with cis-diamindicloroplatinum (cis-DDP) in solutions of different ionic strength was studied by flow birefringence, viscometry, circular dichroism. Though cis-DDP is not an electrolyte, electrostatic interactions are important for binding of cis-DDP with DNA probably for transporting cis-DDP to a macromolecule. The charges aqua-complex is formed by cis-DDP. The complexation being dependent on the platinum/DNA ratio in solution. Along with the increase of platinum concentration, it forms first the complexes with phosphate groups, then with bases without destruction of the DNA secondary structure. The next type of complex formation is accompanied by the local destruction of the hydrogen bonds and stacking interactions. And when the Pt/DNA ratio grows high enough, DNA is denatured. It is suggested that the stability of the complex is provided by nitrogen groups of the bases incorporated in the platinum first coordination sphere. The phosphate DNA groups play the role of counterions in the external coordination sphere.

UR - http://www.scopus.com/inward/record.url?scp=0029042551&partnerID=8YFLogxK

M3 - Article

C2 - 7783739

AN - SCOPUS:0029042551

VL - 29

SP - 345

EP - 353

JO - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

JF - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

SN - 0026-8984

IS - 2

ER -

ID: 73394159