Abstract: The structural and physicochemical mechanisms of interaction of bone tissue with titanium implants under conditions of tuberculous osteitis are studied using scanning electron microscopy, X-ray diffraction analysis, IR spectroscopy, and thermal analysis. Physiological regeneration of bone tissue during treatment of tuberculous osteitis is accompanied by an increase in the organic component, embrittlement of the mineral phase of the bone matrix, and its decomposition to fine particles. The presence of titanium implants under physiological conditions contributes to the activation of the synthesis of the apatite phase in the regenerating bone. The primary mechanism of implantation osteogenesis in tuberculous osteitis is the formation of an inorganic phase of hydroxyapatite mainly in the regions of destruction of the titanium alloy.