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Structure and functions of syndecans in vertebrates. / Leonova, E. I.; Galzitskaya, O. V.

In: Biochemistry (Moscow), Vol. 78, No. 10, 01.10.2013, p. 1071-1085.

Research output: Contribution to journalReview articlepeer-review

Harvard

Leonova, EI & Galzitskaya, OV 2013, 'Structure and functions of syndecans in vertebrates', Biochemistry (Moscow), vol. 78, no. 10, pp. 1071-1085. https://doi.org/10.1134/S0006297913100015

APA

Leonova, E. I., & Galzitskaya, O. V. (2013). Structure and functions of syndecans in vertebrates. Biochemistry (Moscow), 78(10), 1071-1085. https://doi.org/10.1134/S0006297913100015

Vancouver

Leonova EI, Galzitskaya OV. Structure and functions of syndecans in vertebrates. Biochemistry (Moscow). 2013 Oct 1;78(10):1071-1085. https://doi.org/10.1134/S0006297913100015

Author

Leonova, E. I. ; Galzitskaya, O. V. / Structure and functions of syndecans in vertebrates. In: Biochemistry (Moscow). 2013 ; Vol. 78, No. 10. pp. 1071-1085.

BibTeX

@article{8536fa32e1804464a76001d754b7e812,
title = "Structure and functions of syndecans in vertebrates",
abstract = "Syndecans constitute a family of transmembrane proteoglycans that perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. Through mediating binding of a great number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions regulating, thereby, various processes in a cell: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. In fibroblasts, syndecans are responsible for cell adhesion by modulating functions of integrins through interaction with fibronectin at the external side of a cell and with cytoskeleton and signaling molecules inside the cell. The extracellular domain of syndecans is subjected to periodic shedding from the cell membrane. This process may be stimulated in response to inflammation, tissue damage, and other pathological manifestations. Cleaved domain may act as either competitive inhibitor or activator of signaling cascades. This review summarizes and analyzes the available data regarding structure, main biochemical properties, and functions of syndecans in vertebrates.",
keywords = "chondroitin sulfate, extracellular matrix, heparan sulfate, proteoglycan, syndecan",
author = "Leonova, {E. I.} and Galzitskaya, {O. V.}",
year = "2013",
month = oct,
day = "1",
doi = "10.1134/S0006297913100015",
language = "English",
volume = "78",
pages = "1071--1085",
journal = "Biochemistry (Moscow)",
issn = "0006-2979",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "10",

}

RIS

TY - JOUR

T1 - Structure and functions of syndecans in vertebrates

AU - Leonova, E. I.

AU - Galzitskaya, O. V.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Syndecans constitute a family of transmembrane proteoglycans that perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. Through mediating binding of a great number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions regulating, thereby, various processes in a cell: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. In fibroblasts, syndecans are responsible for cell adhesion by modulating functions of integrins through interaction with fibronectin at the external side of a cell and with cytoskeleton and signaling molecules inside the cell. The extracellular domain of syndecans is subjected to periodic shedding from the cell membrane. This process may be stimulated in response to inflammation, tissue damage, and other pathological manifestations. Cleaved domain may act as either competitive inhibitor or activator of signaling cascades. This review summarizes and analyzes the available data regarding structure, main biochemical properties, and functions of syndecans in vertebrates.

AB - Syndecans constitute a family of transmembrane proteoglycans that perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. Through mediating binding of a great number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions regulating, thereby, various processes in a cell: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. In fibroblasts, syndecans are responsible for cell adhesion by modulating functions of integrins through interaction with fibronectin at the external side of a cell and with cytoskeleton and signaling molecules inside the cell. The extracellular domain of syndecans is subjected to periodic shedding from the cell membrane. This process may be stimulated in response to inflammation, tissue damage, and other pathological manifestations. Cleaved domain may act as either competitive inhibitor or activator of signaling cascades. This review summarizes and analyzes the available data regarding structure, main biochemical properties, and functions of syndecans in vertebrates.

KW - chondroitin sulfate

KW - extracellular matrix

KW - heparan sulfate

KW - proteoglycan

KW - syndecan

UR - http://www.scopus.com/inward/record.url?scp=84886938181&partnerID=8YFLogxK

U2 - 10.1134/S0006297913100015

DO - 10.1134/S0006297913100015

M3 - Review article

C2 - 24237141

AN - SCOPUS:84886938181

VL - 78

SP - 1071

EP - 1085

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 10

ER -

ID: 45420350