Research output: Contribution to journal › Review article › peer-review
Structure and functions of syndecans in vertebrates. / Leonova, E. I.; Galzitskaya, O. V.
In: Biochemistry (Moscow), Vol. 78, No. 10, 01.10.2013, p. 1071-1085.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Structure and functions of syndecans in vertebrates
AU - Leonova, E. I.
AU - Galzitskaya, O. V.
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Syndecans constitute a family of transmembrane proteoglycans that perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. Through mediating binding of a great number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions regulating, thereby, various processes in a cell: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. In fibroblasts, syndecans are responsible for cell adhesion by modulating functions of integrins through interaction with fibronectin at the external side of a cell and with cytoskeleton and signaling molecules inside the cell. The extracellular domain of syndecans is subjected to periodic shedding from the cell membrane. This process may be stimulated in response to inflammation, tissue damage, and other pathological manifestations. Cleaved domain may act as either competitive inhibitor or activator of signaling cascades. This review summarizes and analyzes the available data regarding structure, main biochemical properties, and functions of syndecans in vertebrates.
AB - Syndecans constitute a family of transmembrane proteoglycans that perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. Through mediating binding of a great number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions regulating, thereby, various processes in a cell: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. In fibroblasts, syndecans are responsible for cell adhesion by modulating functions of integrins through interaction with fibronectin at the external side of a cell and with cytoskeleton and signaling molecules inside the cell. The extracellular domain of syndecans is subjected to periodic shedding from the cell membrane. This process may be stimulated in response to inflammation, tissue damage, and other pathological manifestations. Cleaved domain may act as either competitive inhibitor or activator of signaling cascades. This review summarizes and analyzes the available data regarding structure, main biochemical properties, and functions of syndecans in vertebrates.
KW - chondroitin sulfate
KW - extracellular matrix
KW - heparan sulfate
KW - proteoglycan
KW - syndecan
UR - http://www.scopus.com/inward/record.url?scp=84886938181&partnerID=8YFLogxK
U2 - 10.1134/S0006297913100015
DO - 10.1134/S0006297913100015
M3 - Review article
C2 - 24237141
AN - SCOPUS:84886938181
VL - 78
SP - 1071
EP - 1085
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - 10
ER -
ID: 45420350