Stress response is the main trigger of sporadic amyloidoses

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Stress response is the main trigger of sporadic amyloidoses. / Galkin, Alexey P.; Sysoev, Evgeniy I.

In: International Journal of Molecular Sciences, Vol. 22, No. 8, 4092, 15.04.2021.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{c471228b79974f19828166b59233a3e7,

title = "Stress response is the main trigger of sporadic amyloidoses",

abstract = "Amyloidoses are a group of diseases associated with the formation of pathological protein fibrils with cross-β structures. Approximately 5–10% of the cases of these diseases are determined by amyloidogenic mutations, as well as by transmission of infectious amyloids (prions) between organisms. The most common group of so-called sporadic amyloidoses is associated with abnormal aggregation of wild-type proteins. Some sporadic amyloidoses are known to be induced only against the background of certain pathologies, but in some cases the cause of amyloidosis is unclear. It is assumed that these diseases often occur by accident. Here we present facts and hypotheses about the association of sporadic amyloidoses with vascular pathologies, trauma, oxidative stress, cancer, metabolic diseases, chronic infections and COVID-19. Generalization of current data shows that all sporadic amyloidoses can be regarded as a secondary event occurring against the background of diseases provoking a cellular stress response. Various factors causing the stress response provoke protein overproduction, a local increase in the concentration or modifications, which contributes to amyloidogenesis. Progress in the treatment of vascular, metabolic and infectious diseases, as well as cancers, should lead to a significant reduction in the risk of sporadic amyloidoses.",

keywords = "Amyloid, Modifications, Protein overpro-duction, Sporadic amyloidoses, Stress response, Trigger of amyloidosis, trigger of amyloidosis, amyloid, stress response, protein overproduction, sporadic amyloidoses, modifications",

author = "Galkin, {Alexey P.} and Sysoev, {Evgeniy I.}",

year = "2021",

month = apr,

day = "15",

doi = "10.3390/ijms22084092",

language = "English",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "MDPI AG",

number = "8",

}

RIS

TY - JOUR

T1 - Stress response is the main trigger of sporadic amyloidoses

AU - Galkin, Alexey P.

AU - Sysoev, Evgeniy I.

PY - 2021/4/15

Y1 - 2021/4/15

N2 - Amyloidoses are a group of diseases associated with the formation of pathological protein fibrils with cross-β structures. Approximately 5–10% of the cases of these diseases are determined by amyloidogenic mutations, as well as by transmission of infectious amyloids (prions) between organisms. The most common group of so-called sporadic amyloidoses is associated with abnormal aggregation of wild-type proteins. Some sporadic amyloidoses are known to be induced only against the background of certain pathologies, but in some cases the cause of amyloidosis is unclear. It is assumed that these diseases often occur by accident. Here we present facts and hypotheses about the association of sporadic amyloidoses with vascular pathologies, trauma, oxidative stress, cancer, metabolic diseases, chronic infections and COVID-19. Generalization of current data shows that all sporadic amyloidoses can be regarded as a secondary event occurring against the background of diseases provoking a cellular stress response. Various factors causing the stress response provoke protein overproduction, a local increase in the concentration or modifications, which contributes to amyloidogenesis. Progress in the treatment of vascular, metabolic and infectious diseases, as well as cancers, should lead to a significant reduction in the risk of sporadic amyloidoses.

AB - Amyloidoses are a group of diseases associated with the formation of pathological protein fibrils with cross-β structures. Approximately 5–10% of the cases of these diseases are determined by amyloidogenic mutations, as well as by transmission of infectious amyloids (prions) between organisms. The most common group of so-called sporadic amyloidoses is associated with abnormal aggregation of wild-type proteins. Some sporadic amyloidoses are known to be induced only against the background of certain pathologies, but in some cases the cause of amyloidosis is unclear. It is assumed that these diseases often occur by accident. Here we present facts and hypotheses about the association of sporadic amyloidoses with vascular pathologies, trauma, oxidative stress, cancer, metabolic diseases, chronic infections and COVID-19. Generalization of current data shows that all sporadic amyloidoses can be regarded as a secondary event occurring against the background of diseases provoking a cellular stress response. Various factors causing the stress response provoke protein overproduction, a local increase in the concentration or modifications, which contributes to amyloidogenesis. Progress in the treatment of vascular, metabolic and infectious diseases, as well as cancers, should lead to a significant reduction in the risk of sporadic amyloidoses.

KW - Amyloid

KW - Modifications

KW - Protein overpro-duction

KW - Sporadic amyloidoses

KW - Stress response

KW - Trigger of amyloidosis

KW - trigger of amyloidosis

KW - amyloid

KW - stress response

KW - protein overproduction

KW - sporadic amyloidoses

KW - modifications

UR - http://www.scopus.com/inward/record.url?scp=85104138521&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/e1ef835d-55c0-3cb7-98a5-52fc74ed394a/

U2 - 10.3390/ijms22084092

DO - 10.3390/ijms22084092

M3 - Review article

AN - SCOPUS:85104138521

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 8

M1 - 4092

ER -

ID: 76136736