Standard

Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method. / Medinskaia, K.; Garmonov, S.; Kozak, J.; Wieczorek, M.; Andruch, V.; Ko cielniak, P.; Bulatov, A.

In: Microchemical Journal, 2015, p. 111-117.

Research output: Contribution to journal › Article

Harvard

Medinskaia, K, Garmonov, S, Kozak, J, Wieczorek, M, Andruch, V, Ko cielniak, P & Bulatov, A 2015, 'Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method', Microchemical Journal, pp. 111-117. https://doi.org/10.1016/j.microc.2015.05.024

APA

Medinskaia, K., Garmonov, S., Kozak, J., Wieczorek, M., Andruch, V., Ko cielniak, P., & Bulatov, A. (2015). Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method. Microchemical Journal, 111-117. https://doi.org/10.1016/j.microc.2015.05.024

Vancouver

Medinskaia K, Garmonov S, Kozak J, Wieczorek M, Andruch V, Ko cielniak P et al. Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method. Microchemical Journal. 2015;111-117. https://doi.org/10.1016/j.microc.2015.05.024

Author

Medinskaia, K. ; Garmonov, S. ; Kozak, J. ; Wieczorek, M. ; Andruch, V. ; Ko cielniak, P. ; Bulatov, A. / Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method. In: Microchemical Journal. 2015 ; pp. 111-117.

BibTeX

@article{e3613893c1c44800aa75e4966478cbd2,
title = "Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method",
abstract = "{\textcopyright} 2015 Elsevier B.V.Novel simple and fully automated procedure - the stepwise injection analysis (SWIA) coupled with the generalized calibration method (GCM) - has been suggested for the automation of spectrophotometric analysis of complex sample matrices. The performance of the suggested approach is demonstrated by the SWIA spectrophotometric determination of isoniazid (INH) in human urine samples. The method is based on the determination of complex between ammonium metavanadate (AMV) and INH in the presence of citrate ions which was excreted with the patient's urine in acidic medium with subsequent UV-VIS spectrophotometric detection. The conditions of complex formation have been studied for flow procedure. In order to detect, reduce matrix interferences and exclude manual sample predilution the GCM was applied. The linear ranges were from 1 to 100mM of INH in human urine samples, and the detection limit, calculated as 3s of a blank test (n=5), was found to be 0.3mM. The relative standard deviation of 5mM o",
author = "K. Medinskaia and S. Garmonov and J. Kozak and M. Wieczorek and V. Andruch and {Ko cielniak}, P. and A. Bulatov",
year = "2015",
doi = "10.1016/j.microc.2015.05.024",
language = "English",
pages = "111--117",
journal = "Microchemical Journal",
issn = "0026-265X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Stepwise injection determination of isoniazid in human urine samples coupled with generalized calibration method

AU - Medinskaia, K.

AU - Garmonov, S.

AU - Kozak, J.

AU - Wieczorek, M.

AU - Andruch, V.

AU - Ko cielniak, P.

AU - Bulatov, A.

PY - 2015

Y1 - 2015

N2 - © 2015 Elsevier B.V.Novel simple and fully automated procedure - the stepwise injection analysis (SWIA) coupled with the generalized calibration method (GCM) - has been suggested for the automation of spectrophotometric analysis of complex sample matrices. The performance of the suggested approach is demonstrated by the SWIA spectrophotometric determination of isoniazid (INH) in human urine samples. The method is based on the determination of complex between ammonium metavanadate (AMV) and INH in the presence of citrate ions which was excreted with the patient's urine in acidic medium with subsequent UV-VIS spectrophotometric detection. The conditions of complex formation have been studied for flow procedure. In order to detect, reduce matrix interferences and exclude manual sample predilution the GCM was applied. The linear ranges were from 1 to 100mM of INH in human urine samples, and the detection limit, calculated as 3s of a blank test (n=5), was found to be 0.3mM. The relative standard deviation of 5mM o

AB - © 2015 Elsevier B.V.Novel simple and fully automated procedure - the stepwise injection analysis (SWIA) coupled with the generalized calibration method (GCM) - has been suggested for the automation of spectrophotometric analysis of complex sample matrices. The performance of the suggested approach is demonstrated by the SWIA spectrophotometric determination of isoniazid (INH) in human urine samples. The method is based on the determination of complex between ammonium metavanadate (AMV) and INH in the presence of citrate ions which was excreted with the patient's urine in acidic medium with subsequent UV-VIS spectrophotometric detection. The conditions of complex formation have been studied for flow procedure. In order to detect, reduce matrix interferences and exclude manual sample predilution the GCM was applied. The linear ranges were from 1 to 100mM of INH in human urine samples, and the detection limit, calculated as 3s of a blank test (n=5), was found to be 0.3mM. The relative standard deviation of 5mM o

U2 - 10.1016/j.microc.2015.05.024

DO - 10.1016/j.microc.2015.05.024

M3 - Article

SP - 111

EP - 117

JO - Microchemical Journal

JF - Microchemical Journal

SN - 0026-265X

ER -

ID: 4000357