Standard

Stable deuterium labeling of histidine-rich lysine-based dendrimers. / Sheveleva, Nadezhda N. ; Markelov, Denis A. ; Vovk, Mikhail A. ; Tarasenko, Irina I. ; Mikhailova, Mariya E. ; Ilyash, Maxim Yu ; Neelov, Igor M. ; Lahderanta, Erkki.

In: Molecules, Vol. 24, No. 13, 2481, 06.07.2019, p. 2481.

Research output: Contribution to journal › Article › peer-review

Harvard

Sheveleva, NN, Markelov, DA, Vovk, MA, Tarasenko, II, Mikhailova, ME, Ilyash, MY, Neelov, IM & Lahderanta, E 2019, 'Stable deuterium labeling of histidine-rich lysine-based dendrimers', Molecules, vol. 24, no. 13, 2481, pp. 2481. https://doi.org/10.3390/molecules24132481

APA

Sheveleva, N. N., Markelov, D. A., Vovk, M. A., Tarasenko, I. I., Mikhailova, M. E., Ilyash, M. Y., Neelov, I. M., & Lahderanta, E. (2019). Stable deuterium labeling of histidine-rich lysine-based dendrimers. Molecules, 24(13), 2481. [2481]. https://doi.org/10.3390/molecules24132481

Vancouver

Sheveleva NN, Markelov DA, Vovk MA, Tarasenko II, Mikhailova ME, Ilyash MY et al. Stable deuterium labeling of histidine-rich lysine-based dendrimers. Molecules. 2019 Jul 6;24(13):2481. 2481. https://doi.org/10.3390/molecules24132481

Author

Sheveleva, Nadezhda N. ; Markelov, Denis A. ; Vovk, Mikhail A. ; Tarasenko, Irina I. ; Mikhailova, Mariya E. ; Ilyash, Maxim Yu ; Neelov, Igor M. ; Lahderanta, Erkki. / Stable deuterium labeling of histidine-rich lysine-based dendrimers. In: Molecules. 2019 ; Vol. 24, No. 13. pp. 2481.

BibTeX

@article{669774825ff04b68ad1e04fb5d04a21c,
title = "Stable deuterium labeling of histidine-rich lysine-based dendrimers",
abstract = "Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising candidates as nanocarriers for drugs and genes. The development of this kind of delivery system requires reliable monitoring of their metabolic and biological pathways. In this respect, hydrogen isotope labeling has tremendous importance, being a safe tool for detection of the labeled nanocarriers. In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. The presence of His residues has enabled us to perform controlled deuteration of Lys-2His dendrimers. The high deuteration degree (around 70%) does not practically change after redissolving the samples in H2O and heating them at 40◦C, which indicates the isotopic label stability.",
keywords = "peptide dendrimer, deuterium labeling, histidine, Deuterium labeling, Histidine, Peptide dendrimer, deuterium labeling, ANALOGS, SIMULATION, PEPTIDES, NMR RELAXATION, BIOMEDICAL APPLICATIONS, EXCHANGE, IMIDAZOLE, PROTEINS, RESIDUES, histidine, peptide dendrimer",
author = "Sheveleva, {Nadezhda N.} and Markelov, {Denis A.} and Vovk, {Mikhail A.} and Tarasenko, {Irina I.} and Mikhailova, {Mariya E.} and Ilyash, {Maxim Yu} and Neelov, {Igor M.} and Erkki Lahderanta",
year = "2019",
month = jul,
day = "6",
doi = "10.3390/molecules24132481",
language = "English",
volume = "24",
pages = "2481",
journal = "Molecules",
issn = "1420-3049",
publisher = "MDPI AG",
number = "13",

}

RIS

TY - JOUR

T1 - Stable deuterium labeling of histidine-rich lysine-based dendrimers

AU - Sheveleva, Nadezhda N.

AU - Markelov, Denis A.

AU - Vovk, Mikhail A.

AU - Tarasenko, Irina I.

AU - Mikhailova, Mariya E.

AU - Ilyash, Maxim Yu

AU - Neelov, Igor M.

AU - Lahderanta, Erkki

PY - 2019/7/6

Y1 - 2019/7/6

N2 - Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising candidates as nanocarriers for drugs and genes. The development of this kind of delivery system requires reliable monitoring of their metabolic and biological pathways. In this respect, hydrogen isotope labeling has tremendous importance, being a safe tool for detection of the labeled nanocarriers. In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. The presence of His residues has enabled us to perform controlled deuteration of Lys-2His dendrimers. The high deuteration degree (around 70%) does not practically change after redissolving the samples in H2O and heating them at 40◦C, which indicates the isotopic label stability.

AB - Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising candidates as nanocarriers for drugs and genes. The development of this kind of delivery system requires reliable monitoring of their metabolic and biological pathways. In this respect, hydrogen isotope labeling has tremendous importance, being a safe tool for detection of the labeled nanocarriers. In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. The presence of His residues has enabled us to perform controlled deuteration of Lys-2His dendrimers. The high deuteration degree (around 70%) does not practically change after redissolving the samples in H2O and heating them at 40◦C, which indicates the isotopic label stability.

KW - peptide dendrimer

KW - deuterium labeling

KW - histidine

KW - Deuterium labeling

KW - Histidine

KW - Peptide dendrimer

KW - deuterium labeling

KW - ANALOGS

KW - SIMULATION

KW - PEPTIDES

KW - NMR RELAXATION

KW - BIOMEDICAL APPLICATIONS

KW - EXCHANGE

KW - IMIDAZOLE

KW - PROTEINS

KW - RESIDUES

KW - histidine

KW - peptide dendrimer

UR - http://www.scopus.com/inward/record.url?scp=85068717605&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/stable-deuterium-labeling-histidinerich-lysinebased-dendrimers

U2 - 10.3390/molecules24132481

DO - 10.3390/molecules24132481

M3 - Article

C2 - 31284551

AN - SCOPUS:85068717605

VL - 24

SP - 2481

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 13

M1 - 2481

ER -

ID: 43615818