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Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin. / Kas'ianenko, N. A.; Aia, E. E.; Bogdanov, A. A.; Kosmotynskaia, I. V.; Iakovlev, K. I.

In: Molekuliarnaia biologiia, Vol. 36, No. 4, 2002, p. 745-752.

Research output: Contribution to journal › Article › peer-review

Harvard

Kas'ianenko, NA, Aia, EE, Bogdanov, AA, Kosmotynskaia, IV & Iakovlev, KI 2002, 'Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin.', Molekuliarnaia biologiia, vol. 36, no. 4, pp. 745-752.

APA

Kas'ianenko, N. A., Aia, E. E., Bogdanov, A. A., Kosmotynskaia, I. V., & Iakovlev, K. I. (2002). Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin. Molekuliarnaia biologiia, 36(4), 745-752.

Vancouver

Kas'ianenko NA, Aia EE, Bogdanov AA, Kosmotynskaia IV, Iakovlev KI. Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin. Molekuliarnaia biologiia. 2002;36(4):745-752.

Author

Kas'ianenko, N. A. ; Aia, E. E. ; Bogdanov, A. A. ; Kosmotynskaia, I. V. ; Iakovlev, K. I. / Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin. In: Molekuliarnaia biologiia. 2002 ; Vol. 36, No. 4. pp. 745-752.

BibTeX

@article{ca982fa6142b4a7dab5803011d2af731,
title = "Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin.",
abstract = "Conformational properties of DNA molecule upon its complexation with binuclear compounds of bivalent platinum in the cis configuration containing pyrazine ligand were studied by circular dichroism, viscometry, and dynamic birefringence. Comparison with active antitumor therapeutic cis-diamminedichloroplatinum (cis-DDP) was made. Experimental data indicates that interaction of these compounds with DNA results in the formation of coordination bond of platinum with nitrogen bases. The structure of the complex depends on the ratio of platinum and DNA concentrations in initial solution. The study of DNA protonation in complex with the binuclear coordination compound showed that the binding of platinum with DNA bases occurs at the N7 atom of guanine. It was observed a competition between the studied compound and cis-DDP for binding site on DNA. The macromolecule binds stronger to the binuclear platinum compound as compared with cis-DDP.",
author = "Kas'ianenko, {N. A.} and Aia, {E. E.} and Bogdanov, {A. A.} and Kosmotynskaia, {I. V.} and Iakovlev, {K. I.}",
note = "Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",
year = "2002",
language = "русский",
volume = "36",
pages = "745--752",
journal = "МОЛЕКУЛЯРНАЯ БИОЛОГИЯ",
issn = "0026-8984",
publisher = "Российская академия наук",
number = "4",

}

RIS

TY - JOUR

T1 - Sravnenie kompleksoobrazovaniia DNK s protivoopukholevym preparatom tsis-DDP i biiadernym soedineniem dvykhvalentnoi platiny, soderzhashchim pirazin.

AU - Kas'ianenko, N. A.

AU - Aia, E. E.

AU - Bogdanov, A. A.

AU - Kosmotynskaia, I. V.

AU - Iakovlev, K. I.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2002

Y1 - 2002

N2 - Conformational properties of DNA molecule upon its complexation with binuclear compounds of bivalent platinum in the cis configuration containing pyrazine ligand were studied by circular dichroism, viscometry, and dynamic birefringence. Comparison with active antitumor therapeutic cis-diamminedichloroplatinum (cis-DDP) was made. Experimental data indicates that interaction of these compounds with DNA results in the formation of coordination bond of platinum with nitrogen bases. The structure of the complex depends on the ratio of platinum and DNA concentrations in initial solution. The study of DNA protonation in complex with the binuclear coordination compound showed that the binding of platinum with DNA bases occurs at the N7 atom of guanine. It was observed a competition between the studied compound and cis-DDP for binding site on DNA. The macromolecule binds stronger to the binuclear platinum compound as compared with cis-DDP.

AB - Conformational properties of DNA molecule upon its complexation with binuclear compounds of bivalent platinum in the cis configuration containing pyrazine ligand were studied by circular dichroism, viscometry, and dynamic birefringence. Comparison with active antitumor therapeutic cis-diamminedichloroplatinum (cis-DDP) was made. Experimental data indicates that interaction of these compounds with DNA results in the formation of coordination bond of platinum with nitrogen bases. The structure of the complex depends on the ratio of platinum and DNA concentrations in initial solution. The study of DNA protonation in complex with the binuclear coordination compound showed that the binding of platinum with DNA bases occurs at the N7 atom of guanine. It was observed a competition between the studied compound and cis-DDP for binding site on DNA. The macromolecule binds stronger to the binuclear platinum compound as compared with cis-DDP.

UR - http://www.scopus.com/inward/record.url?scp=0036652855&partnerID=8YFLogxK

M3 - статья

C2 - 12173482

AN - SCOPUS:0036652855

VL - 36

SP - 745

EP - 752

JO - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

JF - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

SN - 0026-8984

IS - 4

ER -

ID: 73392614