Abstract: The review considers works published over the past 5 years on the synthesis, modifications, and application of chiral catalysts based on squaramides in organic synthesis. The data are grouped by types of reactions catalyzed by squaramide organocatalysts: Michael, Mannich, Pictet–Spengler, Friedel–Crafts, Henry reactions, aldol condensation, cycloaddition. For each reaction, a mechanism is considered that demonstrates the catalytic effect of squaramide organocatalysts.