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Spinal cord injury reveals multilineage differentiation of ependymal cells. / Meletis, Konstantinos; Barnabé-Heider, Fanie; Carlén, Marie; Evergren, Emma; Tomilin, Nikolay; Shupliakov, Oleg; Frisén, Jonas.

In: PLoS Biology, Vol. 6, No. 7, e182, 01.07.2008, p. 1494-1507.

Research output: Contribution to journal › Article › peer-review

Harvard

Meletis, K, Barnabé-Heider, F, Carlén, M, Evergren, E, Tomilin, N, Shupliakov, O & Frisén, J 2008, 'Spinal cord injury reveals multilineage differentiation of ependymal cells', PLoS Biology, vol. 6, no. 7, e182, pp. 1494-1507. https://doi.org/10.1371/journal.pbio.0060182

APA

Meletis, K., Barnabé-Heider, F., Carlén, M., Evergren, E., Tomilin, N., Shupliakov, O., & Frisén, J. (2008). Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biology, 6(7), 1494-1507. [e182]. https://doi.org/10.1371/journal.pbio.0060182

Vancouver

Meletis K, Barnabé-Heider F, Carlén M, Evergren E, Tomilin N, Shupliakov O et al. Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biology. 2008 Jul 1;6(7):1494-1507. e182. https://doi.org/10.1371/journal.pbio.0060182

Author

Meletis, Konstantinos ; Barnabé-Heider, Fanie ; Carlén, Marie ; Evergren, Emma ; Tomilin, Nikolay ; Shupliakov, Oleg ; Frisén, Jonas. / Spinal cord injury reveals multilineage differentiation of ependymal cells. In: PLoS Biology. 2008 ; Vol. 6, No. 7. pp. 1494-1507.

BibTeX

@article{b98fbd67c55a44ef8e282c6abc156a42,
title = "Spinal cord injury reveals multilineage differentiation of ependymal cells",
abstract = "Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.",
author = "Konstantinos Meletis and Fanie Barnab{\'e}-Heider and Marie Carl{\'e}n and Emma Evergren and Nikolay Tomilin and Oleg Shupliakov and Jonas Fris{\'e}n",
year = "2008",
month = jul,
day = "1",
doi = "10.1371/journal.pbio.0060182",
language = "English",
volume = "6",
pages = "1494--1507",
journal = "PLoS Biology",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Spinal cord injury reveals multilineage differentiation of ependymal cells

AU - Meletis, Konstantinos

AU - Barnabé-Heider, Fanie

AU - Carlén, Marie

AU - Evergren, Emma

AU - Tomilin, Nikolay

AU - Shupliakov, Oleg

AU - Frisén, Jonas

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.

AB - Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.

UR - http://www.scopus.com/inward/record.url?scp=48349122033&partnerID=8YFLogxK

U2 - 10.1371/journal.pbio.0060182

DO - 10.1371/journal.pbio.0060182

M3 - Article

C2 - 18651793

AN - SCOPUS:48349122033

VL - 6

SP - 1494

EP - 1507

JO - PLoS Biology

JF - PLoS Biology

SN - 1544-9173

IS - 7

M1 - e182

ER -

ID: 40831297